{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T15:21:51Z","timestamp":1770996111440,"version":"3.50.1"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10957,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,9]]},"abstract":"\n \n The mechanism of polycythemia associated with the Budd\u2013Chiari syndrome is unknown. Erythropoiesis in 10 patients with Budd\u2013Chiari syndrome was studied in an attempt to distinguish prior unrecognized polycythemia vera from secondary polycythemia.<\/jats:p>\n Serum erythropoietin was assayed using a mouse fetal liver erythroblast assay. High concentrations of serum erythropoietin were observed in 6 of 7 patients with acute primary Budd\u2013Chiari syndrome. Levels were normal in four patients who were investigated during the chronic phase and were increased in one with persisting polycythemia. In one patient, erythropoietin concentration in the hepatic vein was twice the level measured in peripheral, caval and renal venous blood.<\/jats:p>\n Bone marrow erythroid progenitors developed in vitro<\/jats:italic> in the absence of exogenous erythropoietin in all polycythemia vera cases studied in acute and chronic phases, whether polycythemia persisted or not.<\/jats:p>\n These findings indicate that hepatic erythropoietin production occurs in the acute phase of Budd\u2013Chiari syndrome and suggest that, in some cases of Budd Chiari syndrome, polycythemia which resolves after the acute phase may be secondary to liver disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hep.1840050525","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T19:13:55Z","timestamp":1172949235000},"page":"858-861","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":29,"title":["Polycythemia and the Budd\u2013Chiari Syndrome: Study of Serum Erythropoietin and Bone Marrow Erythroid Progenitors"],"prefix":"10.1097","volume":"5","author":[{"given":"Victor Georges","family":"Levy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Ruskone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Baillou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Thierman-Duffaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Najman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges Albert","family":"Boffa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840050525-BIB1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005792-195912000-00002","volume":"38","author":"Parker","year":"1959","journal-title":"Medicine"},{"key":"10.1002\/hep.1840050525-BIB2","first-page":"1175","volume":"122","author":"Thomas","year":"1971","journal-title":"Ann Med Interne"},{"key":"10.1002\/hep.1840050525-BIB3","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1210\/endo-88-6-1519","volume":"88","author":"Stephenson","year":"1971","journal-title":"Endocrinology"},{"key":"10.1002\/hep.1840050525-BIB4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-2141.1981.tb02731.x","volume":"48","author":"Napier","year":"1981","journal-title":"Br J Haematol"},{"key":"10.1002\/hep.1840050525-BIB5","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1182\/blood.V58.6.1171.1171","volume":"58","author":"De Klerck","year":"1981","journal-title":"Blood"},{"key":"10.1002\/hep.1840050525-BIB6","author":"Boffa","year":"1978","unstructured":", , et al. \u201cIn vitro\u201d bioassay for minute erythropoietin quantities using foetal mouse liver cells. XVIII Congress of International Society of Hematology. Paris, France, 1978, p. 678."},{"key":"10.1002\/hep.1840050525-BIB7","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1182\/blood.V44.4.517.517","volume":"44","author":"MacLeod","year":"1974","journal-title":"Blood"},{"key":"10.1002\/hep.1840050525-BIB8","first-page":"7001","volume":"45","author":"Levy","year":"1977","journal-title":"Syndrome de Budd Chiari: Le Concours M\u00e9dical"},{"key":"10.1002\/hep.1840050525-BIB9","first-page":"77","volume":"29","author":"Caroli","year":"1971","journal-title":"M\u00e9decine et Hygi\u00e9ne"},{"key":"10.1002\/hep.1840050525-BIB10","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/0002-9343(80)90367-8","volume":"68","author":"Brown","year":"1980","journal-title":"Am J Med"},{"key":"10.1002\/hep.1840050525-BIB11","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1126\/science.847471","volume":"196","author":"Naughton","year":"1977","journal-title":"Sciences"},{"key":"10.1002\/hep.1840050525-BIB12","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1182\/blood.V59.2.447.447","volume":"59","author":"Casadeval","year":"1982","journal-title":"Blood"},{"key":"10.1002\/hep.1840050525-BIB13","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2141.1982.tb03894.x","volume":"52","author":"Anderson","year":"1982","journal-title":"Br J Haematol"},{"key":"10.1002\/hep.1840050525-BIB14","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1172\/JCI109003","volume":"61","author":"Prchal","year":"1978","journal-title":"J Clin Invest"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840050525","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198509000-00024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:00:42Z","timestamp":1733050842000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198509000-00024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,9]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1985]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840050525","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1985,9]]}}}