{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T19:29:29Z","timestamp":1769455769062,"version":"3.49.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10896,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,11]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Biochemical indicators of vitamin A status were measured in 24 children (1 month to 6 years old) with severe cholestasis starting early in life and in 21 children (3 months to 13 years old) with liver disease but without cholestasis. Liver vitamin A concentrations, expressed as micrograms of retinol per gram of liver (mean \u00b1 S.D.), were 6.3 \u00b1 7.1 (range: 0.14 to 28) and 143 \u00b1 108 (range: 18 to 424), respectively, in cholestatic and noncholestatic children. In infants &lt; 6 months of age, liver vitamin A values &lt; 10 \u03bcg per gm were found in 14 of 17 cholestatic children but in none of 3 noncholestatic subjects. Plasma vitamin A values, expressed as micrograms of retinol per deciliter (mean \u00b1 S.D.), were 23 \u00b1 18 (range: 3 to 62) and 46 \u00b1 33 (range: 14 to 125), respectively, for the two groups. Plasma retinol values &lt; 10 \u03bcg per dl were always associated with liver concentrations &lt; 10 \u03bcg per gm. Plasma retinol\u2013binding protein was only reduced to 71% of control values in cholestatic children. The fatty acid composition of liver retinyl esters was unaffected by any condition studied. Infants with chronic cholestasis are in a precarious nutritional status very early in life relative to liver reserves of vitamin A. Plasma vitamin A values, unless &lt; 10 \u03bcg retinol per dl, are poor indicators of inadequate vitamin A status.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840050614","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T19:42:33Z","timestamp":1172950953000},"page":"1143-1148","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":39,"title":["Biochemical Indicators of Vitamin A Depletion in Children With Cholestasis"],"prefix":"10.1097","volume":"5","author":[{"given":"Olivier","family":"Am\u00e9d\u00e9e-Manesme","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold C.","family":"Furr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Hadchouel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Alagille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Allen","family":"Olson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840050614-BIB1","first-page":"211","volume-title":"Vitamins in medicine","author":"Barker","year":"1976","unstructured":"Vitamin A. In: , eds. Vitamins in medicine. 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Biochemical methodology for the assessment of vitamin A status. International Vitamin A Consultative Group. Washington, D.C.: The Nutrition Foundation, 1982."},{"key":"10.1002\/hep.1840050614-BIB11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0019-2791(65)90004-2","volume":"2","author":"Mancini","year":"1965","journal-title":"Immunochemistry"},{"key":"10.1002\/hep.1840050614-BIB12","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1016\/S0021-9258(18)97256-X","volume":"240","author":"Huang","year":"1965","journal-title":"J Biol Chem"},{"key":"10.1002\/hep.1840050614-BIB13","volume-title":"Statistical methods","author":"Snedecor","year":"1967","unstructured":". Statistical methods, 6th ed. 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