{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T05:02:42Z","timestamp":1733115762505,"version":"3.30.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10896,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,11]]},"abstract":"\n \n To evaluate the effects of anaerobic conditions and inducers for the mixed\u2013function oxidase system on the metabolism of mitomycin C, a bioreductive alkylating agent widely used for the treatment of hepatocellular carcinoma, experiments so designed were performed in rats and mice. Metabolism of mitomycin C by microsomes from normal rat liver and diethyl\u2013nitrosamine\u2013induced mouse hepatocellular carcinoma tissue was assessed from the disappearance of the quinone portion of mitomycin C and by measurement of alkylating metabolites using 4\u2013(p<\/jats:italic>\u2013nitrobenzyl)pyridine as a trapping agent. The metabolism of mitomycin C measured by the two independent methods was strikingly increased under anaerobic conditions in both intact and tumor tissues. Since involvement of cytochrome P\u2013450 in the metabolic activation of mitomycin C was shown recently, effects of representative inducers for the mixed\u2013function oxidase system on the metabolism of mitomycin C were also studied. Phenobarbital treatment resulted in a significant increase in the metabolism of mitomycin C in both intact and tumor tissues under anaerobic conditions. The markedly enhanced formation of active metabolites of mitomycin C under anaerobic conditions may explain on a metabolic basis, at least in part, our recent clinical observations that chemoembolizations with microcapsular forms of mitomycin C is more effective than conventional bolus administration of this agent in the treatment of hepatocellular carcinoma. Combination of anaerobic conditions and induction of the mixed\u2013function oxidase system may be applicable to chemotherapy of hepatic malignancy.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hep.1840050621","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T19:42:33Z","timestamp":1172950953000},"page":"1190-1193","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Hypoxia and Phenobarbital Treatment on the Metabolism of Mitomycin C in Experimental Animals"],"prefix":"10.1097","volume":"5","author":[{"given":"Fumio","family":"Nomura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Ohnishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Koen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Iida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Hatano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunio","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840050621-BIB1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1126\/science.142.3596.1181","volume":"142","author":"Schwartz","year":"1963","journal-title":"Science"},{"key":"10.1002\/hep.1840050621-BIB2","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1016\/0006-2952(82)90414-2","volume":"31","author":"Kennedy","year":"1982","journal-title":"Biochem Pharmacol"},{"key":"10.1002\/hep.1840050621-BIB3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1148\/radiology.152.1.6203138","volume":"152","author":"Ohnishi","year":"1984","journal-title":"Radiology"},{"key":"10.1002\/hep.1840050621-BIB4","first-page":"1232","volume":"35","author":"Lieber","year":"1976","journal-title":"Fed Proc"},{"key":"10.1002\/hep.1840050621-BIB5","first-page":"78","volume":"227","author":"Nomura","year":"1983","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1002\/hep.1840050621-BIB6","first-page":"702","volume":"43","author":"Koen","year":"1983","journal-title":"Cancer Res"},{"key":"10.1002\/hep.1840050621-BIB7","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/S0021-9258(20)82244-3","volume":"239","author":"Omura","year":"1964","journal-title":"J Biol Chem"},{"key":"10.1002\/hep.1840050621-BIB8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"183","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1002\/hep.1840050621-BIB9","first-page":"469","volume-title":"Hepatocellular carcinoma","author":"Okazaki","year":"1976","unstructured":"Systemic chemotherapy of hepatocellular carcinoma. In: , eds. Hepatocellular carcinoma. New York: John Wiley & Sons, 1976: 469\u2013475."},{"key":"10.1002\/hep.1840050621-BIB10","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1002\/1097-0142(197805)41:5<1720::AID-CNCR2820410511>3.0.CO;2-7","volume":"41","author":"Kinami","year":"1978","journal-title":"Cancer"},{"key":"10.1002\/hep.1840050621-BIB11","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/1097-0142(19800701)46:1<14::AID-CNCR2820460103>3.0.CO;2-N","volume":"46","author":"Kato","year":"1980","journal-title":"Cancer"},{"key":"10.1002\/hep.1840050621-BIB12","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/1097-0142(19810801)48:3<674::AID-CNCR2820480303>3.0.CO;2-E","volume":"48","author":"Kato","year":"1981","journal-title":"Cancer"},{"key":"10.1002\/hep.1840050621-BIB13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1148\/radiology.140.1.7244243","volume":"140","author":"Chuang","year":"1981","journal-title":"Radiology"},{"key":"10.1002\/hep.1840050621-BIB14","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1148\/radiology.148.2.6306721","volume":"148","author":"Yamada","year":"1983","journal-title":"Radiology"},{"key":"10.1002\/hep.1840050621-BIB15","first-page":"317","volume":"19","author":"Conney","year":"1967","journal-title":"Pharmacol Rev"},{"key":"10.1002\/hep.1840050621-BIB16","first-page":"277","volume":"31","author":"Lu","year":"1980","journal-title":"Pharmacol Rev"},{"key":"10.1002\/hep.1840050621-BIB17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF02468643","volume":"10","author":"Fujimoto","year":"1980","journal-title":"Jap J Surg"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840050621","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198511000-00020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:14:13Z","timestamp":1733051653000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198511000-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,11]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1985]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840050621","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[1985,11]]}}}