{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T22:08:56Z","timestamp":1758406136553,"version":"3.30.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10896,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,11]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The potential role of bile salts in preventing calcium carbonate precipitation was investigated by studying their interaction of Ca<jats:sup>2<\/jats:sup> and their inhibitory effects on calcium carbonate formation.<\/jats:p>\n            <jats:p>Glycochenodeoxycholate micelles bound more calcium than did glycocholate. At bile salt concentrations exceeding 12.5 m<jats:italic toggle=\"yes\">M<\/jats:italic>, glycoursodeoxycholate bound calcium as well as glycochenodexycholate did. Similar results for calcium binding were observed in mixed micelles of bile salts and lecithin. In bicarbonate (25 or 50 m<jats:italic toggle=\"yes\">M<\/jats:italic>) and CaCl<jats:sub>2<\/jats:sub> (10 m<jats:italic toggle=\"yes\">M<\/jats:italic>) solutions, calcium carbonate formation was inhibited by the bile salts. Glycoursodeoxycholate and glycochenodeoxycholate (25 m<jats:italic toggle=\"yes\">M<\/jats:italic>) prevented calcium carbonate formation which was delayed by glycocholate. This effect is not due to differences between both series of bile salts for calcium binding since glycoursodeoxycholate or glycochenodeoxycholate (25 m<jats:italic toggle=\"yes\">M<\/jats:italic>) more efficiently prevented calcium carbonate precipitation than did 35 m<jats:italic toggle=\"yes\">M<\/jats:italic> glycocholate in spite of the same Ca<jats:sub>2+<\/jats:sub> binding.<\/jats:p>\n            <jats:p>These results suggest that some bile salts may have a specific role in preventing calcium precipitation in bile. The mechanism is unknown. The physical properties of glycoursodeoxycholate and glycochenodeoxycholate do not support a role for CaCO<jats:sub>3<\/jats:sub> precipitation in gallstone calcification during litholytic therapy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840050624","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T19:42:33Z","timestamp":1172950953000},"page":"1209-1212","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Effect of Glycoursodeoxycholate on Precipitation of Calcium Carbonate"],"prefix":"10.1097","volume":"5","author":[{"given":"Chantal","family":"Marteau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri","family":"Portugal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Marie","family":"Pauli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Gerolami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840050624-BIB1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0005-2760(82)90010-8","volume":"711","author":"Rajagopalan","year":"1982","journal-title":"Biochim Biophys Acta"},{"key":"10.1002\/hep.1840050624-BIB2","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0016-5085(80)90670-8","volume":"78","author":"Williamson","year":"1980","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840050624-BIB3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0006-291X(83)91261-5","volume":"110","author":"Multigner","year":"1983","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1002\/hep.1840050624-BIB4","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/S0021-9258(17)40603-X","volume":"252","author":"Shlesinger","year":"1977","journal-title":"J Biol Chem"},{"key":"10.1002\/hep.1840050624-BIB5","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1126\/science.212.4501.1397","volume":"212","author":"Wheeler","year":"1981","journal-title":"Science"},{"key":"10.1002\/hep.1840050624-BIB6","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1136\/bmj.283.6292.645","volume":"283","author":"Bateson","year":"1981","journal-title":"Br Med J"},{"key":"10.1002\/hep.1840050624-BIB7","first-page":"1995","volume":"4","author":"Hofmann","year":"1984","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840050624-BIB8","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1016\/S0016-5085(82)80077-2","volume":"83","author":"Moore","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840050624-BIB9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0022-2275(20)39841-2","volume":"21","author":"Igimi","year":"1980","journal-title":"J Lipid Res"},{"key":"10.1002\/hep.1840050624-BIB10","first-page":"301","volume-title":"Bile acids and cholesterol in health and disease","author":"Hofmann","year":"1983","unstructured":"Pharmacology of chenodeoxycholic and ursodeoxycholic acid in man: bile acids and cholesterol in health and diseases. In: , , eds. Bile acids and cholesterol in health and disease. England: MTP Press, 1983: 301\u2013336."},{"key":"10.1002\/hep.1840050624-BIB11","doi-asserted-by":"crossref","first-page":"228s","DOI":"10.1002\/hep.1840040842","volume":"4","author":"Moore","year":"1984","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840050624-BIB12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0022-2275(20)38175-X","volume":"23","author":"Armstrong","year":"1982","journal-title":"J Lipid Res"},{"key":"10.1002\/hep.1840050624-BIB13","doi-asserted-by":"crossref","first-page":"80s","DOI":"10.1002\/hep.1840040815","volume":"4","author":"Mysels","year":"1984","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840050624-BIB14","first-page":"223","volume-title":"Bile acids and cholesterol in health and disease","author":"Montet","year":"1983","unstructured":", , et al. Intestinal cholesterol uptake from mixed micelles\u2014Effects of micellar size and detergent capacity. In: , , eds. Bile acids and cholesterol in health and disease. England: MTP Press, 1983: 223\u2013233."}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840050624","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198511000-00023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:14:02Z","timestamp":1733051642000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198511000-00023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,11]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1985]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840050624","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[1985,11]]}}}