{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:37:54Z","timestamp":1778657874884,"version":"3.51.4"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10835,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>\u03b2<jats:sub>2<\/jats:sub>-Microglobulin display was examined in 131 liver biopsies from patients with acute and chronic type B hepatitis, using an indirect immunoperoxidase method. Enhanced expression of \u03b2<jats:sub>2<\/jats:sub>-microglobulin on hepatocyte membranes was observed in patients with acute hepatitis, chronic active hepatitis with moderate to severe activity and cirrhosis, when compared with normal liver. In acute hepatitis, \u03b2<jats:sub>2<\/jats:sub>-microglobulin\u2013positive hepatocytes were mainly observed in perivenular areas in association with bridging necrosis. In chronic hepatitis, \u03b2<jats:sub>2<\/jats:sub>-microglobulin\u2013positive hepatocytes were observed mainly in periportal zones and in some areas of lobular activty.<\/jats:p>\n            <jats:p>Diffuse\u2013enhanced display of \u03b2<jats:sub>2<\/jats:sub>-microglobulin on hepatocytes was observed in 5 of 6 patients treated with lymphoblastoid interferon as part of a trial of antiviral therapy. The mechanism by which \u03b2<jats:sub>2<\/jats:sub>-microglobulin display is enhanced on hepatocytes in patients not treated with interferon is uncertain. However, display of \u03b2<jats:sub>2<\/jats:sub>-microglobulin on hepatocytes probably reflects display of HLA\u2013A, B and C antigens and may influence the course of hepatitis B virus infection by increasing susceptibility of the affectedcells to T cell\u2013mediated immune attack.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840060105","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T19:38:59Z","timestamp":1172950739000},"page":"20-23","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":35,"title":["Expression Of \u03b2 2-Microglobulin on Hepatocytes in Acute and Chronic Type B Hepatitis"],"prefix":"10.1097","volume":"6","author":[{"given":"Yukihisa","family":"Nagafuchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Scheuer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840060105-BIB1","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1073\/pnas.74.9.4002","volume":"74","author":"Terhorst","year":"1977","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hep.1840060105-BIB2","first-page":"126","volume":"21","author":"Strominger","year":"1974","journal-title":"Transplant Res"},{"key":"10.1002\/hep.1840060105-BIB3","doi-asserted-by":"crossref","first-page":"342","DOI":"10.4049\/jimmunol.123.1.342","volume":"123","author":"Parham","year":"1979","journal-title":"J Immunol"},{"key":"10.1002\/hep.1840060105-BIB4","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1399-0039.1978.tb01233.x","volume":"11","author":"Arce-Gomez","year":"1978","journal-title":"Tissue Antigens"},{"key":"10.1002\/hep.1840060105-BIB5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/oxfordjournals.bmb.a071986","volume":"40","author":"Dongworth","year":"1984","journal-title":"Br Med Bull"},{"key":"10.1002\/hep.1840060105-BIB6","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1136\/gut.22.12.985","volume":"22","author":"Barbatis","year":"1981","journal-title":"Gut"},{"key":"10.1002\/hep.1840060105-BIB7","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/eji.1830061115","volume":"6","author":"Governa","year":"1976","journal-title":"Eur J Immunol"},{"key":"10.1002\/hep.1840060105-BIB8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/jcp.27.1.14","volume":"27","author":"Taylor","year":"1974","journal-title":"J Clin Pathol"},{"key":"10.1002\/hep.1840060105-BIB9","doi-asserted-by":"crossref","first-page":"116s","DOI":"10.1002\/hep.1840020610","volume":"2","author":"Thomas","year":"1982","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840060105-BIB10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/hep.1840020508","volume":"2","author":"Montano","year":"1982","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840060105-BIB11","doi-asserted-by":"crossref","first-page":"6215","DOI":"10.1073\/pnas.75.12.6215","volume":"75","author":"Heron","year":"1978","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hep.1840060105-BIB12","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1073\/pnas.70.10.2785","volume":"70","author":"Lindahl","year":"1973","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hep.1840060105-BIB13","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1073\/pnas.73.4.1284","volume":"73","author":"Lindahl","year":"1976","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hep.1840060105-BIB14","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0140-6736(82)91751-2","volume":"1","author":"Levin","year":"1982","journal-title":"Lancet"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840060105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198601000-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:06:04Z","timestamp":1733051164000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198601000-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840060105","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1986,1]]}}}