{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:37:03Z","timestamp":1773664623556,"version":"3.50.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10835,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Although primary hepatoma is not very frequent in alcoholics, the incidence of hepatoma in cases of hepatitis B infection combined with heavy alcohol drinking is high. In the present study, the effects of chronic alcohol administration onthe development of chemicalinduced hepatic cancer in rats were analyzed. In 70% hepatectomized Wistar strain male rats, asingle dose (1 mg per 100 gm body weight) of diethylnitrosamine was injected intraperitoneally. Eight weeks after the injection, 20% alcohol\u201310% sucrose solution (diethylnitrosamine\u2013alcohol group), 0.1% sodium phenobarbital solution (diethylnitrosamine\u2013phenobarbital group), 10% sucrose solution (diethylnitrosamine\u2013sucrose group) or tap water (diethylnitrosamine\u2013alone group) was given as drinking water for 32 weeks. The numbers of visible nodules per liver were significantly greater in the diethylnitrosamine\u2013alcohol and diethylnitrosamine\u2013phenobarbital groups compared to the diethylnitrosaminealone and diethylnitrosamine\u2013sucrose groups. The numbers of enzyme\u2013altered foci which were positive to \u03b3\u2013glutamyl transpeptidase staining per square centimeter of liver section were also greater in the diethylnitrosamine\u2013alcohol and diethylnitrosamine\u2013phenobarbital groups than in the diethylnitrosamine\u2013alone and diethylnitrosamine\u2013sucrose groups, although the numbers of nodules and enzyme\u2013altered foci were significantly larger in the diethylnitrosamine\u2013phenobarbital group than in the diethylnitrosamine\u2013alcohol group. The enzyme\u2013altered foci areas calculated by \u03b3\u2013glutamyl transpeptidase staining were significantly larger in the diethylnitrosamine\u2013alcohol and diethylnitrosamine\u2013phenobarbital groups than in the diethylnitrosamine\u2013alone and diethylnitrosamine\u2013sucrose groups. Histologically, visible nodules observed in diethylnitrosamine\u2013phenobarbital and diethylnitrosamine\u2013alcohol groups showed characteristic features of neoplastic nodules. These results indicate that alcohol has a promoter action on the development of chemically induced hepatic cancer like phenobarbital.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840060113","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T19:38:59Z","timestamp":1172950739000},"page":"65-72","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":50,"title":["Effects of Ethanol on Experimental 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