{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:30:59Z","timestamp":1788280259190,"version":"build-2803163510"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10835,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>In a study of severe, decompensated liver failure, we tried to find a correlation between hemorrhage and parameters ofhemostasis and fibrinolysis. Three groups of patients were studied: alcoholic cirrhosis; nonalcoholic cirrhosis, and acute liver failure without known prior liver disease. The two cirrhotic groups did not differ significantly from each other in coagulation or in fibrinolytic parameters, although liver function was more impaired in nonalcoholic cirrhosis. The levels of clotting factors, antithrombin III, prekallikrein, plasminogen and \u03b1<jats:sub>2<\/jats:sub>-antiplasmin were significantly lower in the third group. Mean values of fibrinolytic activity (fibrin plate method) were slightly reduced as compared to normal in all three groups. Tissue plasminogen activator\u2013related antigen tended to be elevated especially in alcoholic cirrhosis. The free fast\u2013acting plasminogen activator inhibitor showed extremely high and extremely low levels in some patients among all three groups.<\/jats:p>\n            <jats:p>Nonvariceal, capillary\u2013type bleeding, including mucosal bleeding, hematomas and bleeding from puncture sites correlated with low thrombotest and normotest levels (p &lt; 0.01), low fibrinogen concentration (p &lt; 0.05) and with a high quotient of fibrinolytic activity (square root of lysis area) and normotest (p &lt; 0.001). The ratio between fibrinformation and dissolution appears to be an important parameter of hemorrhagic tendency in liver disease. Variceal bleeding appeared not to be related to impairment of hemostasis or fibrinolysis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840060115","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T19:38:59Z","timestamp":1172950739000},"page":"79-86","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":156,"title":["Hemostasis and Fibrinolysis in Severe Liver Failure and Their Relation to Hemorrhage"],"prefix":"10.1097","volume":"6","author":[{"given":"Anton L.","family":"Boks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emile J.P.","family":"Brommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solko W.","family":"Schalm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huub H.D.M.","family":"Van Vliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840060115-BIB1","first-page":"267","volume-title":"Recent advances in blood coagulation","author":"Poller","year":"1977","unstructured":"Coagulation abnormalities in liver disease. In: ed. Recent advances in blood coagulation. Edinburgh: Churchill Livingstone, 1977: 267\u2013292."},{"key":"10.1002\/hep.1840060115-BIB2","first-page":"301","volume-title":"Progress in liver disease","author":"Flute","year":"1979","unstructured":"Clotting abnormalities in liver disease. In: , eds. . Progress in liver disease. New York: Grune and Stratton, Inc., 1979: 301\u2013312."},{"key":"10.1002\/hep.1840060115-BIB3","first-page":"595","volume-title":"Hemostasis and thrombosis: basic principles and clinical practice","author":"Mannucci","year":"1982","unstructured":". Hemostasis and thrombosis. In: , , et al., eds. Hemostasis and thrombosis: basic principles and clinical practice. Philadelphia: J. B. Lippincott Company, 1982: 595\u2013601."},{"key":"10.1002\/hep.1840060115-BIB4","first-page":"451","volume-title":"Disorders of hemostasis","author":"Ratnoff","year":"1984","unstructured":"Hemostatic defects in liver and biliary track disease and disorders of vitamin K metabolism. In: , eds. Disorders of hemostasis. Orlando, Florida: Grune and Stratton, 1984: 451\u2013471."},{"key":"10.1002\/hep.1840060115-BIB5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1055\/s-0028-1087126","volume":"4","author":"Straub","year":"1977","journal-title":"Thromb Haemost"},{"key":"10.1002\/hep.1840060115-BIB6","first-page":"217","volume":"99","author":"Stein","year":"1982","journal-title":"J Lab Clin Med"},{"key":"10.1002\/hep.1840060115-BIB7","first-page":"280","volume":"60","author":"Pises","year":"1973","journal-title":"Am J Gastroenterol"},{"key":"10.1002\/hep.1840060115-BIB8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1530-0277.1982.tb04973.x","volume":"6","author":"Ragni","year":"1982","journal-title":"Alcoholism: Clin & Exp Res"},{"key":"10.1002\/hep.1840060115-BIB9","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1042\/cs0600681","volume":"60","author":"Chan","year":"1981","journal-title":"Clin Sci"},{"key":"10.1002\/hep.1840060115-BIB10","first-page":"104","volume":"10","author":"Aurousseau","year":"1981","journal-title":"Haemostasis"},{"key":"10.1002\/hep.1840060115-BIB11","first-page":"109","volume":"8","author":"Duckert","year":"1973","journal-title":"Scad J Gastroenterol"},{"key":"10.1002\/hep.1840060115-BIB12","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1172\/JCI109387","volume":"63","author":"Aoki","year":"1979","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840060115-BIB13","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1182\/blood.V59.6.1169.1169","volume":"59","author":"Kluft","year":"1982","journal-title":"Blood"},{"key":"10.1002\/hep.1840060115-BIB14","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1182\/blood.V59.6.1246.1246","volume":"59","author":"Miles","year":"1982","journal-title":"Blood"},{"key":"10.1002\/hep.1840060115-BIB15","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0049-3848(84)90067-7","volume":"34","author":"Brommer","year":"1984","journal-title":"Thromb Res"},{"key":"10.1002\/hep.1840060115-BIB16","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0049-3848(83)90407-3","volume":"31","author":"Chmielewska","year":"1983","journal-title":"Thromb Res"},{"key":"10.1002\/hep.1840060115-BIB17","first-page":"365","volume-title":"Progress in fibrinolysis","author":"Kruithof","year":"1983","unstructured":", . Inhibitor of tissue plasminogen activator by human plasma. In: , , et al., eds. Progress in fibrinolysis, Vol VI. Edinburgh, Churchill Livingstone, 1983: 365\u2013369."},{"key":"10.1002\/hep.1840060115-BIB18","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1055\/s-0038-1661161","volume":"52","author":"Brommer","year":"1984","journal-title":"Thromb Haemost"},{"key":"10.1002\/hep.1840060115-BIB19","first-page":"1812","volume":"26","author":"Ivy","year":"1941","journal-title":"J Lab Clin Med"},{"key":"10.1002\/hep.1840060115-BIB20","volume-title":"Human blood coagulation","author":"Biggs","year":"1976","unstructured":"(Editor). Human blood coagulation, 2nd ed. Oxford: Blackwell Scientific Publications, 1976."},{"key":"10.1002\/hep.1840060115-BIB21","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0140-6736(59)90857-8","volume":"2","author":"Owren","year":"1959","journal-title":"Lancet"},{"key":"10.1002\/hep.1840060115-BIB22","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/978-94-010-3423-4_51","volume-title":"Human blood coagulation","author":"Owren","year":"1969","unstructured":"Normotest in the evaluation of liver function. In: , , eds. Human blood coagulation. Leiden, The Netherlands: Leiden University Press, 1969: 369\u2013378."},{"key":"10.1002\/hep.1840060115-BIB23","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/0049-3848(78)90056-7","volume":"12","author":"Kahl\u00e9","year":"1978","journal-title":"Thromb Res"},{"key":"10.1002\/hep.1840060115-BIB24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000205234","volume":"17","author":"Clauss","year":"1957","journal-title":"Acta Haematol"},{"key":"10.1002\/hep.1840060115-BIB25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0003-2697(66)90246-6","volume":"15","author":"Laurell","year":"1966","journal-title":"Anal Biochem"},{"key":"10.1002\/hep.1840060115-BIB26","first-page":"57","volume-title":"Progress in chemical fibrinolysis and thrombolysis","volume":"2","author":"Kluft","year":"1976","unstructured":", . Screening of fibrinolytic activity in plasma euglobulin fractions on the fibrin plate. In: , , eds. Progress in chemical fibrinolysis and thrombolysis, Vol 2. New York: Raven Press, 1976: 57\u201365."},{"key":"10.1002\/hep.1840060115-BIB27","first-page":"151","volume-title":"Progress in chemical fibrinolysis and thrombolysis","volume":"1","author":"Haverkate","year":"1975","unstructured":". Fibrin plate assay. In: , , eds. Progress in chemical fibrinolysis and thrombolysis, Vol 1. New York: Raven Press, 1975: 151\u2013158."},{"key":"10.1002\/hep.1840060115-BIB28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0049-3848(84)90175-0","volume":"33","author":"Rijken","year":"1984","journal-title":"Thromb Res"},{"key":"10.1002\/hep.1840060115-BIB29","first-page":"138","volume":"7","author":"Friberger","year":"1978","journal-title":"Haemostasis"},{"key":"10.1002\/hep.1840060115-BIB30","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/bjs.1800600817","volume":"60","author":"Pugh","year":"1973","journal-title":"Br J Surg"},{"key":"10.1002\/hep.1840060115-BIB31","first-page":"701","volume":"12","author":"Opolon","year":"1976","journal-title":"Trans Amer Soc Artif Int Organs"},{"key":"10.1002\/hep.1840060115-BIB32","author":"Kwaaitaal","year":"1968","unstructured":". \u201cVarian\u201d programme. Nijmegen University, 1968."},{"key":"10.1002\/hep.1840060115-BIB33","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/B978-1-4831-6756-5.50011-6","volume-title":"Progress in liver disease","author":"Deutsch","year":"1965","unstructured":"Blood coagulation changes in liver disease. In: , eds. Progress in liver disease. New York: Grune & Stratton, 1965: 69\u201383."},{"key":"10.1002\/hep.1840060115-BIB34","first-page":"437","volume":"22","author":"Silk","year":"1979","journal-title":"Br J Hosp Med"},{"key":"10.1002\/hep.1840060115-BIB35","first-page":"313","volume-title":"Recent advances in blood coagulation","volume":"2","author":"Samama","year":"1977","unstructured":", . Congenital and acquired dysfibrinogenaemia. In: ed. Recent advances in blood coagulation, Vol 2. Edinburgh: Churchill Livingstone, 1977: 313\u2013335."},{"key":"10.1002\/hep.1840060115-BIB36","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1055\/s-0038-1654221","volume":"24","author":"Meili","year":"1970","journal-title":"Thromb Diath Haemorrh"},{"key":"10.1002\/hep.1840060115-BIB37","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1600-0609.1974.tb00202.x","volume":"12","author":"Holmberg","year":"1974","journal-title":"Scand J Haemat"},{"key":"10.1002\/hep.1840060115-BIB38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0308-2261(21)00063-1","volume":"8","author":"Bloom","year":"1979","journal-title":"Clinics in Haematol"},{"key":"10.1002\/hep.1840060115-BIB39","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1055\/s-0038-1654891","volume":"14","author":"Van de Loo","year":"1965","journal-title":"Thromb Diath Haemorrh"},{"key":"10.1002\/hep.1840060115-BIB40","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1365-2141.1969.tb01391.x","volume":"17","author":"Das","year":"1969","journal-title":"Br J Haematol"},{"key":"10.1002\/hep.1840060115-BIB41","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000208914","volume":"40","author":"Tytgat","year":"1968","journal-title":"Acta Haematol"},{"key":"10.1002\/hep.1840060115-BIB42","first-page":"209","volume":"2","author":"Brakman","year":"1973\/74","journal-title":"Haemostasis"},{"key":"10.1002\/hep.1840060115-BIB43","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000208253","volume":"52","author":"Mowat","year":"1974","journal-title":"Acta Haematol"},{"key":"10.1002\/hep.1840060115-BIB44","first-page":"5","volume":"37","author":"Herold","year":"1973","journal-title":"Helv Med Acta"},{"key":"10.1002\/hep.1840060115-BIB45","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF02779588","volume":"8","author":"Clark","year":"1973","journal-title":"Scand J Gastroenterol"},{"key":"10.1002\/hep.1840060115-BIB46","first-page":"133","volume":"8","author":"Hillenbrand","year":"1973","journal-title":"Scand J Gastroenterol"},{"key":"10.1002\/hep.1840060115-BIB47","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1365-2141.1975.tb01836.x","volume":"29","author":"Dymock","year":"1975","journal-title":"Br J Haematol"},{"key":"10.1002\/hep.1840060115-BIB48","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1172\/JCI104953","volume":"43","author":"Fletcher","year":"1964","journal-title":"J Clin Invest"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840060115","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198601000-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:06:15Z","timestamp":1733051175000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198601000-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840060115","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1986,1]]}}}