{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T10:49:53Z","timestamp":1792838993783,"version":"4.5.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10592,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,9]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Low values for serum alkaline phosphatase activity were observed early in the course of two patients with Wilson's disease presenting with the combination of severe liver disease and Coombs' negative acute hemolytic anemia. A review of other cases of Wilson's disease revealed that 11 of 12 patients presenting with hemolytic anemia had values for serum alkaline phosphatase less than their respective sex- and age-adjusted mean values; in eight, serum alkaline phosphatase activity was less than the lower value for the normal range of the test. Low values for serum alkaline phosphatase were much less common in Wilson's disease patients with more chronic forms of presentation. Copper added in high concentration to serum in <jats:italic toggle=\"yes\">vitro<\/jats:italic> did not have an important effect on serum alkaline phosphatase activity. The mechanism responsible for the decrease in serum alkaline phosphatase activity in patients is uncertain.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840060509","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T19:53:01Z","timestamp":1172951581000},"page":"859-863","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":92,"title":["Low serum alkaline phosphatase activity in Wilson's disease"],"prefix":"10.1097","volume":"6","author":[{"given":"William A.","family":"Shaver","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshika","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burton","family":"Combes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840060509-BIB1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0016-5085(72)80154-9","volume":"62","author":"Kaplan","year":"1972","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840060509-BIB2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1001\/jama.1970.03170010023004","volume":"211","author":"Elveback","year":"1970","journal-title":"JAMA"},{"key":"10.1002\/hep.1840060509-BIB3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/clinchem\/17.4.275","volume":"17","author":"Reed","year":"1971","journal-title":"Clin Chem"},{"key":"10.1002\/hep.1840060509-BIB4","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/978-1-4613-2970-1_9","volume-title":"Alkaline phosphatase","author":"McComb","year":"1979","unstructured":", . Clinical utilization of alkaline phosphatase measurements. In: Alkaline phosphatase. 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Wilson's disease. In: Major problems in internal medicine, vol 23. Philadelphia, Pennsylvania: W. B. Saunders, 1984: 1\u2013171."},{"key":"10.1002\/hep.1840060509-BIB21","first-page":"497","volume":"102","author":"Wolf","year":"1978","journal-title":"Arch Pathol Lab Med"},{"key":"10.1002\/hep.1840060509-BIB22","first-page":"273","volume":"62","author":"Talbot","year":"1941","journal-title":"Am J Dis Child"},{"key":"10.1002\/hep.1840060509-BIB23","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1056\/NEJM196409102711104","volume":"271","author":"Van Dommelen","year":"1964","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840060509-BIB24","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/00005792-198401000-00002","volume":"63","author":"Fallon","year":"1984","journal-title":"Medicine"},{"key":"10.1002\/hep.1840060509-BIB25","first-page":"172","volume":"26","author":"Prasad","year":"1967","journal-title":"Fed Proc"},{"key":"10.1002\/hep.1840060509-BIB26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/ajcn\/29.2.197","volume":"29","author":"Arakawa","year":"1976","journal-title":"Am J Clin Nutr"},{"key":"10.1002\/hep.1840060509-BIB27","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/978-1-4613-2970-1_7","volume-title":"Alkaline phosphatase","author":"McComb","year":"1979","unstructured":", . 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