{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:53:22Z","timestamp":1791039202646,"version":"4.1.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10531,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,11]]},"abstract":"\n \n A prospective study of apolipoprotein AI has been undertaken in 581 alcoholic patients and in 100 controls in order to describe the changes of apolipoprotein AI according to the different stages of the alcoholic liver disease, to correlate the changes to serum liver tests and to estimate its diagnosis and prognostic value. Results showed that apolipoprotein AI concentration is highly related to the degree of liver injury, reaching a maximum in patients with steatosis (229 \u00b1 90 mg per dl), beginning to decrease in patients with fibrosis (188 \u00b1 88 mg per dl) and reaching a minimum in patients with severe cirrhosis (91 \u00b1 46 mg per dl). Apolipoprotein AI had an independent and discriminative value for the diagnosis of fibrosis (p < 0.001) vs. steatosis and for the diagnosis of cirrhotic vs. noncirrhotic fibrosis (p < 0.001) or vs. acute alcoholic hepatitis without cirrhosis (p < 0.001). Cirrhotic patients with apolipoprotein AI less than 100 mg per dl had a lower survival rate at 1 year (62 \u00b1 7%) than patients with greater value (80 \u00b1 6%; p < 0.05), but this prognostic value disappeared in multivariate analysis when other known prognostic factors were taken into account.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hep.1840060628","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T20:24:50Z","timestamp":1172953490000},"page":"1391-1395","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":44,"title":["Apolipoprotein AI and alcoholic liver disease"],"prefix":"10.1097","volume":"6","author":[{"given":"Thierry","family":"Poynard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Abella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Pignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Naveau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Leluc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Chaput","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840060628-BIB1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0140-6736(75)92376-4","volume":"1","author":"Miller","year":"1975","journal-title":"Lancet"},{"key":"10.1002\/hep.1840060628-BIB2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1161\/01.CIR.62.1.116","volume":"62","author":"Heiss","year":"1980","journal-title":"Circulation"},{"key":"10.1002\/hep.1840060628-BIB3","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/hep.1840030311","volume":"3","author":"Kanel","year":"1983","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840060628-BIB4","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1001\/jama.1985.03350430066027","volume":"253","author":"Camargo","year":"1985","journal-title":"JAMA"},{"key":"10.1002\/hep.1840060628-BIB5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1056\/NEJM198308183090701","volume":"309","author":"Maciejko","year":"1983","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840060628-BIB6","first-page":"237","volume":"30","author":"Malmendier","year":"1983","journal-title":"Hepato-Gastroenterol"},{"key":"10.1002\/hep.1840060628-BIB7","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0002-9343(81)90211-4","volume":"71","author":"Devenyi","year":"1981","journal-title":"Am J Med"},{"key":"10.1002\/hep.1840060628-BIB8","first-page":"739","volume":"12","author":"Chabrier","year":"1983","journal-title":"Presse Med"},{"key":"10.1002\/hep.1840060628-BIB9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0009-8981(84)90312-7","volume":"137","author":"Cordova","year":"1984","journal-title":"Clin Chem Acta"},{"key":"10.1002\/hep.1840060628-BIB10","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/hep.1840040401","volume":"4","author":"Duhamel","year":"1984","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840060628-BIB11","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0140-6736(81)91984-X","volume":"1","author":"Review by an International Group","year":"1981","journal-title":"Lancet"},{"key":"10.1002\/hep.1840060628-BIB12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/00365517209102748","volume":"29","author":"Laurell","year":"1977","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1002\/hep.1840060628-BIB13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/clinchem\/22.3.315","volume":"223","author":"Curry","year":"1976","journal-title":"Clin Chem"},{"key":"10.1002\/hep.1840060628-BIB14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/clinchem\/28.1.59","volume":"38","author":"Fruchart","year":"1982","journal-title":"Clin Chem"},{"key":"10.1002\/hep.1840060628-BIB15","volume-title":"BMDP statistical software 1981","author":"Dixon","year":"1981","unstructured":"BMDP statistical software 1981. 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