{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:30:18Z","timestamp":1791268218786,"version":"4.1.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10470,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The presence of hepatitis B virus DNA and anti-\u03b4 was examined in a longitudinal study of 24 patients known to be \u03b4-infected during the course from acute to chronic hepatitis B virus infection. Fifteen patients (63%) were hepatitis B virus DNA positive in the first serum sample. Eleven of 14 patients, who cleared hepatitis B virus DNA, did so following or at the same time as onset of \u03b4-infection. Duration of hepatitis B virus DNA positivity in these 11 patients was shorter than in 11 anti-\u03b4-negative controls matched according to duration of preceding hepatitis B virus DNA positivity, but the difference was not statistically significant. Considering only patients positive for IgM anti-\u03b4 in the last serum sample (eight patients), a statistically significant shorter duration of hepatitis B virus DNA positivity was found in \u03b4-infected patients than in the controls (p &lt; 0.02). The study indicates that the \u03b4-agent may have the capacity to inhibit hepatitis B virus replication and that a chronic \u03b4-infection may lead to a termination of the period of active viral replication.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840070110","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T20:20:11Z","timestamp":1172953211000},"page":"42-45","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":107,"title":["\u03b4-Infection and suppression of hepatitis B virus replication in chronic HBsAg carriers"],"prefix":"10.1097","volume":"7","author":[{"given":"Kim","family":"Krogsgaard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kryger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Aldershvile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poul","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorkild I. 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