{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:47:17Z","timestamp":1762865237372,"version":"3.30.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10411,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,3]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Two hundred forty-two voluntary blood donors, referred after detection of HBsAg positivity, underwent clinical evaluation and liver biopsy and were prospectively followed for an average of 3.5 years. At initial testing, 65% of HBsAg carriers had normal laboratory findings; during follow-up, 26% of these carriers developed abnormal test results, at least transiently. Liver histology was normal in 31.4%, revealed nonaggressive liver disease in 63.6% and chronic active hepatitis or cirrhosis in 5%, only. All except one case of chronic active hepatitis or cirrhosis were associated with abnormal blood biochemical tests. Sequential liver biopsies obtained in 56 HBsAg carriers after a minimal interval of 4 years showed mitigation of inflammatory changes in 5.4% and developing chronic active hepatitis in three cases (5.4%). One carrier died of primary hepatocellular carcinoma.<\/jats:p>\n            <jats:p>Upon follow-up, HBsAg persisted in 98%. Anti-HBe was found in 90% of all carriers already at the initial testing. HBeAg positivity (7.5%) was associated with chronic active hepatitis as well as nonaggressive liver disease; clearance of HBeAg occurred in 40% after 2 to 8 years. Because of the subclinical progression of liver disease and the increased risk for developing primary hepatocellular carcinoma in asymptomatic HBsAg carriers, routine blood testing, including \u03b1-fetoprotein screening, as well as abdominal ultrasound surveillance are indicated. Liver biopsy, however, should be restricted to carriers with abnormal biochemical findings.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840070215","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T20:12:02Z","timestamp":1172952722000},"page":"302-306","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":69,"title":["Long-term follow-up study of asymptomatic hbsag-positive voluntary blood donors in austria: A clinical and histologic evaluation of 242 cases"],"prefix":"10.1097","volume":"7","author":[{"given":"Brigitte","family":"Dragosics","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ferenci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Hitchman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Denk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840070215-BIB1","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1136\/gut.26.8.848","volume":"26","author":"Anderson","year":"1985","journal-title":"Gut"},{"key":"10.1002\/hep.1840070215-BIB2","first-page":"55","volume":"14","author":"Wewalka","year":"1979","journal-title":"Scand J Gastroenterology"},{"key":"10.1002\/hep.1840070215-BIB3","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0009-9120(81)91078-X","volume":"14","author":"Munjal","year":"1981","journal-title":"Clin Biochem"},{"key":"10.1002\/hep.1840070215-BIB4","first-page":"797","volume-title":"Processes in pathology and microbiology, section 6","author":"Taussig","year":"1984","unstructured":"Viruses and neoplasia. 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