{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:58:10Z","timestamp":1761217090256,"version":"3.30.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10411,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,3]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The photodegradation of chlorpromazine, a drug frequently used in psychotherapy, was examined under different sets of experimental conditions. A primary culture of rat hepatocytes was used to evaluate the possible hepatotoxicity of the chlorpromazine photoproducts, keeping in mind the following criteria: leakage of cytosolic enzymes; attachment index to culture plates, and albumin synthesis. Cells exposed to concentrations greater than 10<jats:sup>\u22124<\/jats:sup>\n                                 <jats:italic toggle=\"yes\">M<\/jats:italic> of the photomixtures showed extensive leakage of GOT and GPT into the culture medium and, at the same time, the cell attachment was seriously impaired. A concentration of 10<jats:sup>\u22127<\/jats:sup>\n                                 <jats:italic toggle=\"yes\">M<\/jats:italic> of the photoproducts proved capable of inhibiting the synthesis of albumin (20%). Photoproducts obtained after aerobic irradiations were as toxic for hepatocytes as those found in anaerobic conditions. The implications of our results in connection with the relevance of oxygen-dependent photoreactions of chlorpromazine to its phototoxicity, and the possible appearance of hepatic alterations in patients treated with the drug after exposure to the sunlight, are discussed.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840070223","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T20:12:02Z","timestamp":1172952722000},"page":"349-354","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Toxic effects of the photoproducts of chlorpromazine on cultured hepatocytes"],"prefix":"10.1097","volume":"7","author":[{"given":"Jos\u00e9 V.","family":"Castell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M. 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