{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:30:05Z","timestamp":1791268205294,"version":"4.1.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10350,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,5]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>To evaluate the effect of hepatitis delta virus on the level of replication of hepatitis B virus and to assess the clinical significance that such an effect might have on the final outcome of the infection, the serological profile of hepatitis B virus DNA was investigated in 153 patients with acute or chronic hepatitis B virus infection with or without associated delta infection. Serum hepatitis B virus DNA was detected in 57% of patients with acute hepatitis B, 67% of those with acute hepatitis B virus-hepatitis delta virus coinfection and 25% of HBsAg carriers with hepatitis delta virus superinfection during the first week after the onset of symptoms. Patients with acute hepatitis B and those with acute hepatitis B virus-hepatitis delta virus coinfection did not differ significantly with respect to the serological profile of hepatitis B virus DNA and final clinical outcome. Within the group of HBsAg carriers with hepatitis delta virus superinfection, all patients who were initially negative for hepatitis B virus DNA developed chronic hepatitis delta virus infection, whereas 3 of the 4 patients with active hepatitis B virus infection at the time of superinfection showed transient inhibition of hepatitis B virus replication followed by termination of hepatitis delta virus infection in two patients. Therefore, although delta virus may inhibit the replication of hepatitis B virus among chronic HBsAg carriers, this effect is not readily apparent among patients with hepatitis B virus-hepatitis delta virus coinfection.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840070325","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T20:48:17Z","timestamp":1172954897000},"page":"569-572","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":36,"title":["Hepatitis b virus replication in acute hepatitis B, acute hepatitis B virus-hepatitis delta virus coinfection and acute hepatitis delta superinfection"],"prefix":"10.1097","volume":"7","author":[{"given":"J.","family":"Genesca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Jardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Buti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Vives","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Prat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. I.","family":"Esteban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Esteban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Guardia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840070325-BIB1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/hep.1840050104","volume":"5","author":"Krogsgaard","year":"1985","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840070325-BIB2","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/hep.1840050512","volume":"5","author":"Krogsgaard","year":"1985","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840070325-BIB3","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0168-8278(85)80010-6","volume":"1","author":"Lok","year":"1985","journal-title":"J Hepatol"},{"key":"10.1002\/hep.1840070325-BIB4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jmv.1890170406","volume":"17","author":"Moestrup","year":"1985","journal-title":"J Med Virol"},{"key":"10.1002\/hep.1840070325-BIB5","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1093\/infdis\/153.5.974","volume":"153","author":"Wu","year":"1986","journal-title":"J Infect Dis"},{"key":"10.1002\/hep.1840070325-BIB6","first-page":"417","volume-title":"Progress in liver diseases","author":"Rizzetto","year":"1986","unstructured":", , et al. Hepatitis delta virus disease. In: , eds. Progress in liver diseases, Vol VIII. Orlando, Florida: Grune and Stratton, 1986: 417\u2013431."},{"key":"10.1002\/hep.1840070325-BIB7","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/infdis\/141.5.590","volume":"121","author":"Rizzetto","year":"1980","journal-title":"J Infect Dis"},{"key":"10.1002\/hep.1840070325-BIB8","first-page":"79","volume-title":"Viral hepatitis and delta infection","author":"Purcell","year":"1983","unstructured":". Experimental transmission of the delta agent to chimpanzees. In: , , eds. Viral hepatitis and delta infection. New York: Alan R. Liss, 1983: 79\u201389."},{"key":"10.1002\/hep.1840070325-BIB9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/bmj.286.6359.87","volume":"286","author":"Moestrup","year":"1983","journal-title":"Br Med J"},{"key":"10.1002\/hep.1840070325-BIB10","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S0140-6736(83)91835-4","volume":"1","author":"Fromme","year":"1983","journal-title":"Lancet"},{"key":"10.1002\/hep.1840070325-BIB11","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1136\/gut.26.2.212","volume":"26","author":"De Cock","year":"1985","journal-title":"Gut"},{"key":"10.1002\/hep.1840070325-BIB12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/jmv.1890090208","volume":"9","author":"Smedile","year":"1982","journal-title":"J Med Virol"},{"key":"10.1002\/hep.1840070325-BIB13","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1600-0676.1982.tb00831.x","volume":"2","author":"Trevisan","year":"1982","journal-title":"Liver"},{"key":"10.1002\/hep.1840070325-BIB14","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/hep.1840010308","volume":"1","author":"Stocklin","year":"1981","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840070325-BIB15","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/hep.1840030301","volume":"3","author":"Scotto","year":"1983","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840070325-BIB16","first-page":"665","volume":"87","author":"Genesca","year":"1986","journal-title":"Med Clin"},{"key":"10.1002\/hep.1840070325-BIB17","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1093\/infdis\/151.5.925","volume":"151","author":"Caredda","year":"1985","journal-title":"J Infect Dis"},{"key":"10.1002\/hep.1840070325-BIB18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0168-8278(86)80003-4","volume":"3","author":"Amoroso","year":"1986","journal-title":"J Hepatol"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840070325","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198705000-00024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:08:35Z","timestamp":1733051315000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198705000-00024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,5]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840070325","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1987,5]]}}}