{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:06Z","timestamp":1760188866327,"version":"3.30.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10289,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,7]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>In a randomized controlled trial, 41 chronic hepatitis B virus carriers were allocated, by opening numbered computerized randomization envelopes, to receive recombinant interferon-\u03b12A at three different doses: 2.5; 5.0, and 10.0 mU per m<jats:sup>2<\/jats:sup>. Thirty-two patients received treatment (6 for 3 months, 26 for 6 months), and 9 patients were controls (received no treatment). Ninety-three per cent of our patients were homosexual, and 41% had anti-HTLV-III in their serum<\/jats:p>\n            <jats:p>None of the control patients lost HBeAg. In contrast, six of the anti-HTLV-III-negative patients (33%) responded to treatment (p &lt; 0.02): five of these responders were homosexual (p &lt; 0.05). The response rate was greatest (44%) in the anti-HTLV-III-negative patients who received 10 mU per m<jats:sup>2<\/jats:sup> of recombinant interferon-\u03b12A. None of the anti-HTLV-III-positive patients responded to treatment. The percentage reduction of hepatitis B virus DNA was significantly less in the anti-HTLV-III-positive group in comparison to the anti-HTLV-III-negative group at 1 and 4 months of treatment and at 3 months after the end of treatment (p &lt; 0.05). These patients were younger (33 vs. 42 years, p &lt; 0.02), had lower mean baseline AST values (42 vs. 80 IU per liter, p &lt; 0.02) and tended to have milder histo-logical disease<\/jats:p>\n            <jats:p>Homosexual men with HBeAg-positive chronic liver disease who are anti-HTLV-III-positive appear to be less responsive to the direct antiviral and immunomodulatory effects of recombinant interferon-\u03b12A. This may be due to the subclinical immunosuppressive effects of co-infection with HTLV-III.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840070417","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T20:47:46Z","timestamp":1172954866000},"page":"719-723","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":118,"title":["Diminished responsiveness of male homosexual chronic hepatitis B virus carriers with HTLV-III antibodies to recombinant \u03b1-interferon"],"prefix":"10.1097","volume":"7","author":[{"given":"J. A.","family":"McDonald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Karayiannis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. J.","family":"Scully","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R. W.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. E.","family":"Forster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. C.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840070417-BIB1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/hep.1840050315","volume":"5","author":"Chu","year":"1985","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840070417-BIB2","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0140-6736(81)90585-7","volume":"2","author":"Beasley","year":"1981","journal-title":"Lancet"},{"key":"10.1002\/hep.1840070417-BIB3","doi-asserted-by":"crossref","first-page":"744","DOI":"10.7326\/0003-4819-94-6-744","volume":"94","author":"Hoofnagle","year":"1981","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840070417-BIB4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/hep.1840010306","volume":"1","author":"Scullard","year":"1981","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840070417-BIB5","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/oxfordjournals.bmb.a072079","volume":"41","author":"Thomas","year":"1985","journal-title":"Br Med Bull"},{"key":"10.1002\/hep.1840070417-BIB6","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/infdis\/148.5.907","volume":"148","author":"Smith","journal-title":"J Infect Dis"},{"key":"10.1002\/hep.1840070417-BIB7","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S0140-6736(85)92324-4","volume":"1","author":"Carne","year":"1985","journal-title":"Lancet"},{"key":"10.1002\/hep.1840070417-BIB8","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0140-6736(79)91376-X","volume":"1","author":"Ellis","year":"1979","journal-title":"Lancet"},{"key":"10.1002\/hep.1840070417-BIB9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0168-8278(85)80065-9","volume":"1","author":"Novick","year":"1985","journal-title":"J Hepatol"},{"year":"1987","author":"Scully","key":"10.1002\/hep.1840070417-BIB10","unstructured":", , et al. Lymphoblastoid interferon therapy of chronic hepatitis B virus infection: a comparison of twelve weeks versus twenty-four weeks of thrice weekly treatment. J Hepatol 1987 (in press)."},{"key":"10.1002\/hep.1840070417-BIB11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0022-1759(82)90042-4","volume":"52","author":"Goodall","year":"1982","journal-title":"J Immunol Meth"},{"key":"10.1002\/hep.1840070417-BIB12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/jmv.1890090405","volume":"9","author":"Weller","year":"1982","journal-title":"J Med Virol"},{"key":"10.1002\/hep.1840070417-BIB13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0168-8278(85)80759-5","volume":"1","author":"Karayiannis","year":"1985","journal-title":"J Hepatol"},{"key":"10.1002\/hep.1840070417-BIB14","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/S0140-6736(81)90600-0","volume":"2","author":"Viola","year":"1981","journal-title":"Lancet"},{"year":"1985","author":"Weller","key":"10.1002\/hep.1840070417-BIB15","unstructured":", , et al. Spontaneous loss of HBeAg in male homosexual hepatitis B virus carriers and implications for therapy. 6th Int STD Conf., 1985; Abstract 78."},{"key":"10.1002\/hep.1840070417-BIB16","doi-asserted-by":"crossref","first-page":"5530","DOI":"10.1073\/pnas.82.16.5530","volume":"82","author":"Salahuddin","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hep.1840070417-BIB17","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/0002-9343(60)90114-5","volume":"29","author":"Good","year":"1960","journal-title":"Am J Med"},{"key":"10.1002\/hep.1840070417-BIB18","doi-asserted-by":"crossref","first-page":"795","DOI":"10.7326\/0003-4819-101-6-795","volume":"101","author":"Rustgi","year":"1984","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840070417-BIB19","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/infdis\/143.6.772","volume":"143","author":"Scullard","year":"1981","journal-title":"J Infect Dis"},{"key":"10.1002\/hep.1840070417-BIB20","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0016-5085(86)90099-5","volume":"90","author":"Gregory","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840070417-BIB21","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/0016-5085(86)90087-9","volume":"90","author":"Dooley","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840070417-BIB22","first-page":"17","volume":"60","author":"Krohn","year":"1985","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840070417-BIB23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.7326\/0003-4819-103-1-37","volume":"103","author":"Nicholson","year":"1985","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840070417-BIB24","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/BF01645949","volume":"12","author":"Abb","year":"1984","journal-title":"Infection"},{"key":"10.1002\/hep.1840070417-BIB25","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/hep.1840020508","volume":"2","author":"Montano","year":"1982","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840070417-BIB26","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/hep.1840060303","volume":"6","author":"Pignatelli","year":"1986","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840070417-BIB27","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev.bi.51.070182.001343","volume":"51","author":"Lergyl","year":"1982","journal-title":"Ann Rev Biochem"},{"key":"10.1002\/hep.1840070417-BIB28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1073\/pnas.77.1.107","volume":"77","author":"Epstein","year":"1980","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hep.1840070417-BIB29","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.4049\/jimmunol.127.4.1585","volume":"127","author":"Hokland","year":"1981","journal-title":"J Immunol"},{"key":"10.1002\/hep.1840070417-BIB30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-97-1-1","volume":"97","author":"Borden","year":"1982","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840070417-BIB31","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0008-8749(80)90342-1","volume":"53","author":"Stanwick","year":"1980","journal-title":"Cell Immunol"},{"key":"10.1002\/hep.1840070417-BIB32","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1365-3083.1981.tb00134.x","volume":"13","author":"Ausiello","year":"1981","journal-title":"Scand J Immunol"},{"key":"10.1002\/hep.1840070417-BIB33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/jmv.1890190110","volume":"19","author":"Thomas","year":"1986","journal-title":"J Med Virol"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840070417","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198707000-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:11:29Z","timestamp":1733051489000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198707000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,7]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840070417","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[1987,7]]}}}