{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T05:23:16Z","timestamp":1738992196398,"version":"3.37.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10166,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The density of HLA Class I antigen on peripheral blood mononuclear cells was evaluated by flow cytometry in the following groups of patients: 41 HBsAg carriers; 12 individuals with chronic non-A, non-B hepatitis, and 4 with acute hepatitis B. Fourteen of the carriers were positive for antibody to human immunodeficiency virus, and all were negative for antibody to delta agent. Elevated levels of Class I antigen were observed in only 19% of patients with chronic hepatitis B virus infection alone. In contrast, 86% of HBsAg carriers with coexistent human immunodeficiency virus infection demonstrated increased expression. These data suggest that HBsAg carriers are capable of sustaining a systemic interferon response to another chronic viral infection and further supports the hypothesis that a defective interferon response exists in chronic hepatitis B virus infection.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840070624","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T21:13:23Z","timestamp":1172956403000},"page":"1326-1329","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Elevated HLA class i antigen expression on peripheral blood mononuclear cells of HBsAg carriers with coexistent human immunodeficiency virus infection"],"prefix":"10.1097","volume":"7","author":[{"given":"Robert G.","family":"Paul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanford T.","family":"Roodman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah A.","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P.","family":"Perrillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840070624-BIB1","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1002\/hep.1840060537","volume":"6","author":"Davis","year":"1986","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840070624-BIB2","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/hep.1840050231","volume":"5","author":"Robinson","year":"1985","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840070624-BIB3","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/hep.1840060525","volume":"6","author":"Ikeda","year":"1986","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840070624-BIB4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/hep.1840060416","volume":"6","author":"Pirovino","year":"1986","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840070624-BIB5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/hep.1840050202","volume":"5","author":"Poitrine","year":"1985","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840070624-BIB6","first-page":"453","volume-title":"Progress in liver diseases","volume":"8","author":"Peters","year":"1986","unstructured":", , . The interferon system in acute and chronic viral hepatitis. In: , eds. Progress in liver diseases, Vol. 8. 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