{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:47:17Z","timestamp":1762865237373,"version":"3.37.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10105,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>A numerical scoring system was applied and compared with conventional histological classification to assess the histological outcome in 42 patients with chronic hepatitis B followed for 16 to 162 months (mean = 75 months). Four histological categories in the biopsies were assessed and scored: (i) piecemeal necrosis; (ii) lobular necrosis; (iii) portal inflammation, and (iv) fibrosis and cirrhosis. The sum of all four categories was defined as the \u201cHistological Activity Index.\u201d Altogether, 102 liver specimens, including 2 to 4 repeats from each patient, were investigated. A good correlation was noted between a high value of the Histological Activity Index score and several liver histology as monitored by conventional terminology for chronic hepatitis. Among patients, with HBeAg persistence, 8 of 14 (57%) deteriorated during follow-up as judged by an increase in the Histological Activity Index score compared to 3 of 13 (23%) of the patients with HBeAg seroconversion (0.5 &lt; p &lt; 0.1). Piecemeal necrosis has been postulated to be a predictive marker for the eventual development of cirrhosis. Here, we found that a low score for piecemeal necrosis in the initial liver biopsy was significantly less predictive of a high fibrosis score in the follow-up biopsy than was a high score for initial piecemeal necrosis (p &lt; 0.001).<\/jats:p>\n            <jats:p>It is concluded that the scoring system used can be applied to monitor the histological long-term follow-up, especially when separated into its four constituent categories. It also offers a means of predicting a chronic hepatitis outcome.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840080120","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T21:03:26Z","timestamp":1172955806000},"page":"98-103","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":16,"title":["The application of a numerical scoring system for evaluating the histological outcome in patients with chronic hepatitis B followed in long term"],"prefix":"10.1097","volume":"8","author":[{"given":"Gudrun","family":"Lindh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola","family":"Weiland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Glaumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840080120-BIB1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/0016-5085(84)90601-2","volume":"86","author":"Hoofnagle","year":"1984","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840080120-BIB2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1600-0676.1984.tb00924.x","volume":"4","author":"Sagnelli","year":"1984","journal-title":"Liver"},{"key":"10.1002\/hep.1840080120-BIB3","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1600-0676.1984.tb00942.x","volume":"4","author":"Liaw","year":"1984","journal-title":"Liver"},{"key":"10.1002\/hep.1840080120-BIB4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1600-0676.1986.tb00264.x","volume":"6","author":"Chu","year":"1986","journal-title":"Liver"},{"key":"10.1002\/hep.1840080120-BIB5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.7326\/0003-4819-98-4-437","volume":"98","author":"Rizzetto","year":"1983","journal-title":"Ann 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