{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:17:24Z","timestamp":1790792244227,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10105,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>In 44 patients with primary biliary cirrhosis serum levels of vitamin A, retinol-binding protein and transthyretin (prealbumin) were found to be significantly lower than in 25 sex- and age-matched controls. Liver biopsies were available for chemical analyses in 28 of the patients. Their mean liver vitamin A concentration (2.8 \u00b1 2.0 \u03bcmoles per gm wet weight) did not differ significantly from that in 22 cases of sudden death which served as controls (2.0 \u00b1 1.5 \u03bcmoles per gm wet weight). Immunohistochemical investigation showed a normal distribution of serum retinol-binding protein in the patients\u2019 livers, whereas the staining pattern of cellular retinol-binding protein, believed to be involved in the intrahepatic transport of vitamin A, was abnormal. Thus, the number size and cellular retinol-binding protein staining intensity of fat-storing (Ito) cells were clearly higher in the patients as compared with controls. The results suggest that the low serum vitamin A levels in primary biliary cirrhosis are not a consequence of vitamin A deficiency but instead reflect a defective mobilization of vitamin A from the liver.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840080126","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T21:03:26Z","timestamp":1172955806000},"page":"136-141","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":42,"title":["Impaired release of vitamin a from liver in primary biliary 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