{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:46:47Z","timestamp":1787856407371,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10045,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,3]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Three of five family members experienced symptoms and biochemical evidence of hepatitis that could not be explained on the basis of infectious, metabolic or immunologic disorders of the liver. A history of prolonged ingestion of moderate amounts of vitamin A (20,000 to 45,000 IU per day for 7 to 10 years) was obtained in each of the three family members and was absent in the remaining two unaffected individuals. A liver biopsy performed in one family member confirmed the diagnosis of vitamin A toxicity. This report emphasizes the finding that even moderate amounts of vitamin A, when ingested over a prolonged period of time, can cause significant hepatocellular injury.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840080214","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T21:33:00Z","timestamp":1172957580000},"page":"272-275","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":45,"title":["Vitamin a hepatotoxicity in multiple family members"],"prefix":"10.1097","volume":"8","author":[{"given":"Gerald Y.","family":"Minuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James K.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Sek","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840080214-BIB1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/ajcn\/36.1.185","volume":"36","author":"Herbert","year":"1982","journal-title":"Am J Clin Nutr"},{"key":"10.1002\/hep.1840080214-BIB2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1001\/archderm.1981.01650030038018","volume":"117","author":"Elias","year":"1981","journal-title":"Arch Dermatol"},{"key":"10.1002\/hep.1840080214-BIB3","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1136\/bmj.281.6246.957","volume":"281","author":"Editorial (Anonymous)","year":"1980","journal-title":"Br Med J"},{"key":"10.1002\/hep.1840080214-BIB4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1530-0277.1979.tb05287.x","volume":"3","author":"McClain","year":"1979","journal-title":"Alcoholism: Clin Exp Res"},{"key":"10.1002\/hep.1840080214-BIB5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0002-9343(71)90212-9","volume":"50","author":"Muenter","year":"1971","journal-title":"Am J Med"},{"key":"10.1002\/hep.1840080214-BIB6","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1056\/NEJM197408292910903","volume":"291","author":"Russell","year":"1974","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840080214-BIB7","first-page":"355","volume":"33","author":"Rosa","year":"1986","journal-title":"Tetralology"},{"key":"10.1002\/hep.1840080214-BIB8","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/archinte.1975.00330080055008","volume":"135","author":"Patek","year":"1975","journal-title":"Arch Intn Med"},{"key":"10.1002\/hep.1840080214-BIB9","year":"1980","unstructured":"Recommended Daily Dietary Allowances. Washington, D.C.: Food and Nutrition Board, National Academy of Sciences, National Research Council, 1980."},{"key":"10.1002\/hep.1840080214-BIB10","first-page":"363","volume":"45","author":"Korner","year":"1975","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1002\/hep.1840080214-BIB11","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1001\/jama.1982.03320340071041","volume":"247","author":"Farris","year":"1982","journal-title":"JAMA"},{"key":"10.1002\/hep.1840080214-BIB12","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/archderm.1979.04010070058027","volume":"115","author":"Shmunes","year":"1979","journal-title":"Arch Dermatol"},{"key":"10.1002\/hep.1840080214-BIB13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hep.1840030101","volume":"3","author":"Leo","year":"1983","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840080214-BIB14","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1056\/NEJM197604082941503","volume":"294","author":"Smith","year":"1976","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840080214-BIB15","first-page":"451","volume":"76","author":"Hruban","year":"1974","journal-title":"Am J Pathol"},{"key":"10.1002\/hep.1840080214-BIB16","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0016-5085(79)80231-0","volume":"76","author":"Jacques","year":"1979","journal-title":"Gastroenterology"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840080214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198803000-00013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T15:05:35Z","timestamp":1738940735000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198803000-00013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,3]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840080214","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1988,3]]}}}