{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:30:55Z","timestamp":1791099055748,"version":"4.1.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":9984,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,5]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Patients suffering from Type I glycogen storage disease frequently develop hepatic tumors. Some of these were classified as carcinoma, with the majority of tumors representing benign adenomata. However, no evidence exists of malignant transformation of adenomata in these patients. Here, we describe the occurrence of a hepatocellular carcinoma in the adenomata-bearing liver of the elder of two sisters suffering from Type I glycogen storage disease at the age of 20 years, 6 years after the diagnosis had been made. Surprisingly, \u03b1-fetoprotein levels were normal throughout the entire course of this patient, whereas the younger sister had elevated levels despite the absence of malignant lesions. Thus, the clinical significance of \u03b1-fetoprotein remains unclear in both cases. Nocturnal feeding, although performed continuously over the 6 years after the diagnosis, had obviously failed to prevent the development of hepatic tumors in both patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840080317","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T21:24:49Z","timestamp":1172957089000},"page":"531-537","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":94,"title":["Hepatocellular carcinoma in type I glycogen storage disease"],"prefix":"10.1097","volume":"8","author":[{"given":"Joachim","family":"Limmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang E.","family":"Fleig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothea","family":"Leupold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Bittner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Ditschuneit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-G\u00fcnter","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840080317-BIB1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1542\/peds.16.6.785","volume":"16","author":"Mason","year":"1955","journal-title":"Pediatrics"},{"key":"10.1002\/hep.1840080317-BIB2","first-page":"1087","volume":"40","author":"Fraumeni","year":"1968","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/hep.1840080317-BIB3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0022-3476(69)80010-7","volume":"74","author":"Zangeneh","year":"1969","journal-title":"J Pediatr"},{"key":"10.1002\/hep.1840080317-BIB4","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1001\/jama.1976.03270140033019","volume":"236","author":"Howell","year":"1976","journal-title":"JAMA"},{"key":"10.1002\/hep.1840080317-BIB5","first-page":"354","volume":"19","author":"Miller","year":"1978","journal-title":"J Nucl Med"},{"key":"10.1002\/hep.1840080317-BIB6","doi-asserted-by":"crossref","first-page":"755","DOI":"10.2337\/diab.18.11.755","volume":"18","author":"Lockwood","year":"1969","journal-title":"Diabetes"},{"key":"10.1002\/hep.1840080317-BIB7","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0022-3476(80)80871-7","volume":"96","author":"Greene","year":"1980","journal-title":"J Pediatr"},{"key":"10.1002\/hep.1840080317-BIB8","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/978-94-009-9215-3_20","volume-title":"Inherited disorders of carbohydrate metabolism","author":"Hug","year":"1980","unstructured":"Pre- and postnatal diagnosis of glycogen storage disease. In: ed. Inherited disorders of carbohydrate metabolism. Lancaster, England: MTP Press, Ltd., 1980: 327\u2013367."},{"key":"10.1002\/hep.1840080317-BIB9","first-page":"141","volume-title":"The metabolic basis of inherited disease","author":"Howell","year":"1983","unstructured":". The glycogen storage disease. In: , , et al., eds. The metabolic basis of inherited disease. New York: McGraw-Hill, 1983: 141\u2013166."},{"key":"10.1002\/hep.1840080317-BIB10","first-page":"217","volume":"605","author":"Bannasch","year":"1980","journal-title":"Biochim Biophys Acta"},{"key":"10.1002\/hep.1840080317-BIB11","first-page":"9","volume":"51","author":"Bannasch","year":"1983","journal-title":"IARC Sci Publ"},{"key":"10.1002\/hep.1840080317-BIB12","first-page":"1","volume":"19","author":"Bannasch","year":"1968","journal-title":"Rec Res Cancer Res"},{"key":"10.1002\/hep.1840080317-BIB13","first-page":"87","volume-title":"Primary liver tumors","author":"Bannasch","year":"1978","unstructured":"Cellular and subcellular pathology of liver carcinogenesis. In: , , et al., eds. Primary liver tumors. Lancaster, England: MTP Press, Ltd., 1978: 87\u2013111."},{"key":"10.1002\/hep.1840080317-BIB14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0065-2571(84)90010-4","volume":"22","author":"Bannasch","year":"1984","journal-title":"Adv Enz Repl"},{"key":"10.1002\/hep.1840080317-BIB15","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1093\/carcin\/3.11.1265","volume":"3","author":"Hacker","year":"1982","journal-title":"Carcinogenesis"},{"key":"10.1002\/hep.1840080317-BIB16","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF02893521","volume":"8","author":"Spycher","year":"1971","journal-title":"Virchow's Arch Abt B Zellpath"},{"key":"10.1002\/hep.1840080317-BIB17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1055\/s-2008-1040649","volume":"4","author":"Goldfarb","year":"1984","journal-title":"Sem Liv Dis"},{"key":"10.1002\/hep.1840080317-BIB18","first-page":"76","volume-title":"Immunodiagnosis of cancer","author":"Abelev","year":"1984","unstructured":"Alpha-fetoprotein in neoplasia. In: , eds. Immunodiagnosis of cancer. New York: Marcel Decker, 1984: 76\u2013101."},{"key":"10.1002\/hep.1840080317-BIB19","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/S0016-5085(84)80151-1","volume":"86","author":"Chen","year":"1984","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840080317-BIB20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0065-230X(08)60523-0","volume":"14","author":"Abelev","year":"1971","journal-title":"Adv Cancer Res"},{"key":"10.1002\/hep.1840080317-BIB21","first-page":"1413","volume":"34","author":"Sell","year":"1974","journal-title":"Cancer Res"},{"key":"10.1002\/hep.1840080317-BIB22","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/0016-5085(79)90238-5","volume":"77","author":"Wespic","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840080317-BIB23","first-page":"153","volume-title":"Laboratory and research methods in biology and medicine","author":"Barroso","year":"1983","unstructured":". Functional evaluation: carcino-embryonic antigen (CEA) and alpha-fetoprotein (AFP) as tumor markers of the liver. In: ed. Laboratory and research methods in biology and medicine. New York: Wiley, 1983: 153\u2013157."},{"key":"10.1002\/hep.1840080317-BIB24","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/0016-5085(81)90606-5","volume":"81","author":"Parker","year":"1981","journal-title":"Gastroenterology"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840080317","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198805000-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T18:44:42Z","timestamp":1742841882000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198805000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,5]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1988]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840080317","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1988,5]]}}}