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Serum ALT levels were normal in 80% of the children at presentation and remained within the normal range during the study in 60%. Fluctuations in ALT levels were mild. In four of 12 instances, transient elevations in ALT levels were associated with a fall in serum hepatitis B virus DNA levels.<\/jats:p>\n            <jats:p>At presentation, 43 (84%) children were hepatitis B e antigen (HBeAg) positive; only two (7%) cleared HBeAg on follow-up. None of the eight children who were initially positive for the antibody to HBeAg reverted back to HBeAg positivity. All the children remained HBsAg positive.<\/jats:p>\n            <jats:p>In this study, we demonstrated that chronic hepatitis B virus infection in asymptomatic Chinese children is usually associated with a mild and stable liver disease despite high levels of hepatitis B virus replication. This may reflect an immunological tolerance to the hepatitis B virus induced by early exposure to the virus and accounts for the persistently high levels of hepatitis B virus replication on follow-up.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840080527","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T21:52:50Z","timestamp":1172958770000},"page":"1130-1133","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":150,"title":["A longitudinal follow-up of asymptomatic hepatitis B surface antigen-positive chinese children"],"prefix":"10.1097","volume":"8","author":[{"given":"Anna S. 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