{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:42:54Z","timestamp":1773034974689,"version":"3.50.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":9588,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,6]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Tin-mesoporphyrin shares many of the properties of its parent compound, tin-protoporphyrin. These include competitive inhibition of heme oxygenase, amelioration of jaundice and suppression of chemically induced hepatic porphyria. Tin-mesoporphyrin is cleared from the plasma of normal subjects with dose-dependent pharmacokinetics (T<jats:sub>1\/2<\/jats:sub> = 3.8 hr following i.v. administration of 1 \u03bcmole per kg body weight), and small amounts (&lt;1% of administered dose) are excreted into the urine and feces. Intramuscular administration of tin-mesoporphyrin resulted, within 2 hr, in plasma concentrations identical to those obtained following i.v. administration, but the compound was not absorbed orally. The only dose-limiting side effect was transient cutaneous photosensitivity. High doses (1 \u03bcmole per kg body weight) of tin-mesoporphyrin resulted in significant decreases in plasma bilirubin concentrations at 24 and 48 h after treatment of normal subjects. Administration of both tin-protoporphyrin and tin-mesoporphyrin resulted in decreases in the urinary excretion of heme pathway intermediates in stable hyperexcreters with acute hepatic porphyria.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840090616","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:08:58Z","timestamp":1172963338000},"page":"882-888","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":34,"title":["Pharmacokinetics of tin-mesoporphyrin in man and the effects of tin-chelated porphyrins on hyperexcretion of heme pathway precursors in patients with acute inducible porphyria"],"prefix":"10.1097","volume":"9","author":[{"given":"Richard A.","family":"Galbraith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attallah","family":"Kappas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840090616-BIB1","doi-asserted-by":"crossref","first-page":"6466","DOI":"10.1073\/pnas.78.10.6466","volume":"78","author":"Drummond","year":"1981","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hep.1840090616-BIB2","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1126\/science.6896768","volume":"217","author":"Drummond","year":"1982","journal-title":"Science"},{"key":"10.1002\/hep.1840090616-BIB3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1172\/JCI111394","volume":"74","author":"Drummond","year":"1984","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840090616-BIB4","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/hep.1840040227","volume":"4","author":"Kappas","year":"1984","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840090616-BIB5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1172\/JCI112309","volume":"77","author":"Kappas","year":"1986","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840090616-BIB6","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1084\/jem.162.3.864","volume":"162","author":"Sassa","year":"1985","journal-title":"J Exp Med"},{"key":"10.1002\/hep.1840090616-BIB7","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/clpt.1986.88","volume":"39","author":"Anderson","year":"1986","journal-title":"Clin Pharmacol Ther"},{"key":"10.1002\/hep.1840090616-BIB8","first-page":"485","volume":"81","author":"Kappas","year":"1988","journal-title":"Pediatrics"},{"key":"10.1002\/hep.1840090616-BIB9","first-page":"327","volume":"228","author":"Anderson","year":"1984","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1002\/hep.1840090616-BIB10","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/hep.1840080331","volume":"8","author":"Berglund","year":"1988","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840090616-BIB11","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1203\/00006450-198501000-00025","volume":"19","author":"Milleville","year":"1985","journal-title":"Pediatr Res"},{"key":"10.1002\/hep.1840090616-BIB12","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1084\/jem.165.4.1195","volume":"165","author":"Landaw","year":"1987","journal-title":"J Exp Med"},{"key":"10.1002\/hep.1840090616-BIB13","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1073\/pnas.82.3.896","volume":"82","author":"Kappas","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hep.1840090616-BIB14","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1172\/JCI111727","volume":"75","author":"Simionatto","year":"1985","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840090616-BIB15","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1172\/JCI112259","volume":"76","author":"Galbraith","year":"1985","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840090616-BIB16","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0003-9861(87)90294-3","volume":"225","author":"Drummond","year":"1987","journal-title":"Arch Biochem Biophys"},{"key":"10.1002\/hep.1840090616-BIB17","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0003-2697(84)90448-2","volume":"141","author":"Simionatto","year":"1984","journal-title":"Anal Biochem"},{"key":"10.1002\/hep.1840090616-BIB18","first-page":"1247","volume-title":"The metabolic basis of inherited disease","author":"Kappas","year":"1989","unstructured":", , et al. 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