{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:18:18Z","timestamp":1774948698544,"version":"3.50.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":9558,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,7]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Recombinant human \u03b1-interferon is now under intensive investigation as therapy for chronic Type B hepatitis. Recent reports have suggested that prolonged \u03b1-interferon therapy may induce autoimmune reactions. We have evaluated the problem of autoimmunity related to \u03b1-interferon therapy by testing for 15 different antibodies in the sera of 31 patients treated with \u03b1-interferon. No patient had autoantibodies before treatment; 27 (87%) of 31 patients developed at least one autoantibody. Eleven patients had antinuclear antibodies and 21 had smooth muscle antibodies, both of which usually developed during \u03b1-interferon therapy. In contrast, antibodies to endocrine organs such as thyroid microsomal, thyroglobulin and parietal cell antibodies arose in 12 patients, but usually several months after \u03b1-interferon treatment. The appearance of these autoantibodies did not correlate with disease activity or response to \u03b1-interferon. No patient developed autoantibodies specifically associated with autoimmune liver diseases such as liver kidney microsomal antibodies, autoantibodies to soluble liver antigen and the primary billiary cirrhosis-specific subtypes of antimitochondrial antibodies.<\/jats:p>\n            <jats:p>These results suggest that prolonged \u03b1-interferon therapy can induce autoantibody production and, in susceptible patients, may lead to autoimmune disorders.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840100106","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T21:44:40Z","timestamp":1172958280000},"page":"24-28","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":133,"title":["Treatment of chronic type B hepatitis with recombinant \u03b1-interferon induces autoantibodies not specific for autoimmune chronic hepatitis"],"prefix":"10.1097","volume":"10","author":[{"given":"Werner-J.","family":"Mayet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Hess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Gerken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegbert","family":"Rossol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Voth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Manns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Hermann Meyer","family":"ZumB\u00fcschenfelde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840100106-BIB1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0140-6736(87)92735-8","volume":"2","author":"Alexander","year":"1987","journal-title":"Lancet"},{"key":"10.1002\/hep.1840100106-BIB2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0171-2985(86)80106-1","volume":"172","author":"Hess","year":"1986","journal-title":"Immunobiology"},{"key":"10.1002\/hep.1840100106-BIB3","doi-asserted-by":"crossref","first-page":"s245","DOI":"10.1016\/S0168-8278(86)80128-3","volume":"3","author":"Hess","year":"1986","journal-title":"J Hepatol"},{"key":"10.1002\/hep.1840100106-BIB4","first-page":"428","volume":"63","author":"Penner","year":"1986","journal-title":"J Immunol"},{"key":"10.1002\/hep.1840100106-BIB5","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-0676.1984.tb00918.x","volume":"4","author":"Kurki","year":"1984","journal-title":"Liver"},{"key":"10.1002\/hep.1840100106-BIB6","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0140-6736(87)92024-1","volume":"2","author":"Manns","year":"1987","journal-title":"Lancet"},{"key":"10.1002\/hep.1840100106-BIB7","first-page":"600","volume":"57","author":"Manns","year":"1984","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840100106-BIB8","volume-title":"Immunodiffusion and immunoelectro-phoresis. 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