{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:28:37Z","timestamp":1789914517716,"version":"4.0.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":9435,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Since interferons have been shown to affect the synthesis of matrix proteins such as collagen in several <jats:italic toggle=\"yes\">in vitro<\/jats:italic> systems, the potential role of \u03b3\u2013interferon in inhibiting hepatic fibrosis was investigated. Hepatic cells, consisting primarily of hepatocytes, were treated with recombinant \u03b3\u2013interferon for 24 hr. Northern blot hybridization showed that \u03b3\u2013interferon treatment caused a profound decrease in pro\u2013\u03b12(I)collagen mRNA levels but an increase in \u03b2\u2013actin mRNA content. The effects of \u03b3\u2013interferon were then studied in an <jats:italic toggle=\"yes\">in vivo<\/jats:italic> model of hepatic fibrogenesis, murine schistosomiasis. <jats:italic toggle=\"yes\">Schistosoma<\/jats:italic>\u2013infected mice were treated with daily i.m. injections of \u03b3\u2013interferon for a 4\u2013week period starting 4 weeks after the initial infection. \u03b3\u2013Interferon treatment decreased collagen deposition as determined by histologic evaluation and measurement of total liver collagen content. Northern blots showed Types I and III procollagen mRNA levels for treated, infected animals to be only 32 and 29% that of infected controls, but \u03b2\u2013actin mRNA levels were significantly elevated. These results indicate a potential role for \u03b3\u2013interferon as an antifibrogenic agent <jats:italic toggle=\"yes\">in vivo<\/jats:italic>.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840100508","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T22:43:45Z","timestamp":1172961825000},"page":"795-800","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":151,"title":["\u03b3\u2013Interferon Treatment Inhibits Collagen Deposition in Murine Schistosomiasis"],"prefix":"10.1097","volume":"10","author":[{"given":"Mark J.","family":"Czaja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis 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