{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:28:19Z","timestamp":1787956099360,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":9435,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>To determine whether a serum parameter of collagen metabolism, serum procollagen type III peptide, correlated with hepatic collagen in a model of diet\u2013induced fibrosis, rats were fed a control or cirrhogenic diet for 6 months and treated with either subcutaneous vehicle or the hepatoprotective prostaglandin 16,16\u2013dimethyl prostaglandin E2 (100 \u03bcg per kg) twice daily. Pair\u2013fed rats from each group were killed after 2, 4 or 6 months. The value of serum procollagen type III peptide to body weight integrated over time (K<jats:sub>t<\/jats:sub>) correlated linearly with hepatic hydroxyproline content (r = 0.97) at killing time t. Good correlations were also seen between K<jats:sub>t<\/jats:sub> and histopathological assessment of aniline blue\u2013stainable collagen (r = 0.93) and between the histopathology and hydroxyproline content (r = 0.97). Rats receiving 16,16\u2013dimethyl prostaglandin E<jats:sub>2<\/jats:sub> had lower values of all three parameters compared to rats receiving vehicle, confirming the previously demonstrated hepatoprotective effect of 16,16\u2013dimethyl prostaglandin E<jats:sub>2<\/jats:sub>. The excellent correlation between K<jats:sub>t<\/jats:sub> and the two other traditional parameters of hepatic collagen suggest that sequential measurements of serum procollagen type III peptide can be used to predict alterations in liver collagen deposition in rats.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840100509","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T22:43:45Z","timestamp":1172961825000},"page":"801-806","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":78,"title":["The Integrated Value of Serum Procollagen Iii Peptide Over Time Predicts Hepatic Hydroxyproline Content and Stainable Collagen in A Model of Dietary Cirrhosis in the Rat"],"prefix":"10.1097","volume":"10","author":[{"given":"Mary J.","family":"Ruwart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen F.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob D.","family":"Rush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Vidmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith S.","family":"Henley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry D.","family":"Appelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoung Y.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Schuppan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckert G.","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840100509-BIB1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/978-3-642-70048-4_7","volume-title":"Alcohol related diseases in gastroenterology","author":"Hahn","year":"1985","unstructured":". Ethanol and fibrogenesis in the liver. In: , eds. Alcohol related diseases in gastroenterology. Berlin: Springer Verlag, 1985: 124\u2013153."},{"key":"10.1002\/hep.1840100509-BIB2","first-page":"257","volume-title":"Chronic hepatitis","author":"Ruwart","year":"1986","unstructured":", , et al. The effect of 16,16-dimethylprostaglandin E2 on nutritional injury in rat liver. In: ed. Chronic hepatitis. 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