{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:33:04Z","timestamp":1771633984041,"version":"3.50.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":9435,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Recently, macroregenerative nodules in cirrhotic livers have been suspected to be among the putative precancerous lesions in human hepatocarcinogenesis. We examined the morphologies of 99 macroregenerative nodules in 44 cirrhotic livers with special emphasis on stainable iron. In 26 macroregenerative nodules (26%), stainable iron selectively accumulated within the macroregenerative nodules themselves, and little or no iron was found in the surrounding regenerative nodules. In nine macroregenerative nodules (9%), an appreciable amount of stainable iron was present in both the macroregenerative nodules and the surrounding regenerative nodules. In the remaining 64 macroregenerative nodules (65%), stainable iron was absent in both the macroregenerative nodules and the surrounding regenerative nodules. Hyperplastic hepatocellular foci were present within 19 (73%) of the 26 iron\u2013accumulative macroregenerative nodules, one (11%) of the nine iron\u2013positive macroregenerative nodules and 20 (31%) of the 64 iron\u2013negative macroregenerative nodules. These findings suggest that iron\u2013accumulative macroregenerative nodules are frequently associated with hyperplastic hepatocellular foci and should be included among the precancerous lesions in human hepatocellular carcinoma.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840100517","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T22:43:45Z","timestamp":1172961825000},"page":"851-854","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":68,"title":["Survey of Iron\u2013Accumulative Macroregenerative Nodules in Cirrhotic Livers"],"prefix":"10.1097","volume":"10","author":[{"given":"Tadashi","family":"Terada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuni","family":"Nakanuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840100517-BIB1","first-page":"127","volume":"25","author":"Sasaki","year":"1980","journal-title":"Gann Monogr Cancer Res"},{"key":"10.1002\/hep.1840100517-BIB2","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/S0016-5085(88)80093-3","volume":"95","author":"Tsuda","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840100517-BIB3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-4-431-68349-0_13","volume-title":"Neoplasm of the liver","author":"Ohta","year":"1987","unstructured":". Comparative study of the three nodular lesions in cirrhosis. Adenomatoid hyperplasia, adenomatoid hyperplasia with intermediate lesion and small hepatocellular carcinoma. In: , eds. Neoplasm of the liver. Berlin: Springer-Verlag, 1987: 177\u2013187."},{"key":"10.1002\/hep.1840100517-BIB4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0016-5085(86)90458-0","volume":"91","author":"Arakawa","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840100517-BIB5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1440-1746.1986.tb01750.x","volume":"1","author":"Arakawa","year":"1986","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1002\/hep.1840100517-BIB6","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1002\/1097-0142(19841201)54:11<2487::AID-CNCR2820541129>3.0.CO;2-M","volume":"54","author":"Nagasue","year":"1984","journal-title":"Cancer"},{"key":"10.1002\/hep.1840100517-BIB7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/1097-0142(19880101)61:1<99::AID-CNCR2820610117>3.0.CO;2-U","volume":"61","author":"Furuya","year":"1988","journal-title":"Cancer"},{"key":"10.1002\/hep.1840100517-BIB8","first-page":"42","volume":"19","author":"Halliday","year":"1982","journal-title":"Semin Hematol"},{"key":"10.1002\/hep.1840100517-BIB9","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/hep.1840050528","volume":"5","author":"Bomford","year":"1985","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840100517-BIB10","first-page":"916","volume":"113","author":"Terada","year":"1989","journal-title":"Arch Pathol Lab Med"},{"key":"10.1002\/hep.1840100517-BIB11","first-page":"663","volume":"95","author":"Awai","year":"1979","journal-title":"Am J Pathol"},{"key":"10.1002\/hep.1840100517-BIB12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1172\/JCI110787","volume":"71","author":"Bacon","year":"1983","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840100517-BIB13","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1042\/bj2500589","volume":"250","author":"Ozaki","year":"1988","journal-title":"Biochem J"},{"key":"10.1002\/hep.1840100517-BIB14","first-page":"611","volume":"45","author":"Bromford","year":"1976","journal-title":"Q J Med"},{"key":"10.1002\/hep.1840100517-BIB15","first-page":"107","volume":"76","author":"Ebina","year":"1986","journal-title":"J Natl Cancer Inst"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840100517","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198911000-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T15:20:43Z","timestamp":1738941643000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198911000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1989]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840100517","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1989,11]]}}}