{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:30:37Z","timestamp":1773145837223,"version":"3.50.1"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":9435,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Reducing the size of a liver for use in a recipient smaller than the donor is one way to reduce mortality before orthotopic liver transplantation in children because of the scarcity of pediatric organ donors. In this report, we review the results of this approach over the past 2 years, during which we have used reduced\u2013size orthotopic liver transplantation routinely in small children.<\/jats:p>\n            <jats:p>Forty\u2013nine children underwent orthotopic liver transplantation between September, 1986, and October, 1988; orthotopic liver transplantation with a whole organ (full\u2013size orthotopic liver transplantation) was performed in 36 children, whereas 13 patients received reduced\u2013size orthotopic liver transplantation. In two pairs of patients, the reduced grafts were obtained from single donors, using a \u201csplit\u2013liver\u201d procedure. All grafts were implanted in the orthotopic position following total recipient hepatectomy.<\/jats:p>\n            <jats:p>The preoperative diagnostic categories were not significantly different between groups. Patients receiving reduced\u2013size orthotopic liver transplantation were younger (1.6 \u00b1 1.5 vs. 4.4 \u00b1 4.6 years), and a higher percentage were in the intensive care unit prior to transplant (31 vs. 9%). Thirty of 36 (82%) patients receiving full\u2013size orthotopic liver transplantation and 10 of 13 (77%) patients receiving reduced\u2013size orthotopic liver transplantation are alive 3 to 27 months after transplantation. The rates of retransplantation were 24% for full\u2013size orthotopic liver transplantation and 15% for reduced\u2013size orthotopic liver transplantation.<\/jats:p>\n            <jats:p>Despite the greater complexity of reduced\u2013size ortho\u2013topic liver transplantation and the higher frequency of critically ill recipients selected for the procedure, the results of reduced\u2013size orthotopic liver transplantation are comparable with full\u2013size orthotopic liver transplantation. These results justify the continued use of reduced\u2013size orthotopic liver transplantation in children with end\u2013stage liver disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840100520","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T22:43:45Z","timestamp":1172961825000},"page":"867-872","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":115,"title":["Reduced\u2013Size Orthotopic Liver Transplantation: Use in the Management of Children With Chronic Liver Disease"],"prefix":"10.1097","volume":"10","author":[{"given":"Jean C.","family":"Emond","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter F.","family":"Whitington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Thistlethwaite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estella M.","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph E.","family":"Broelsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840100520-BIB1","first-page":"3230","volume":"19","author":"Starzl","year":"1987","journal-title":"Transplant Proc"},{"key":"10.1002\/hep.1840100520-BIB2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0022-3468(88)80733-4","volume":"23","author":"Otte","year":"1988","journal-title":"J Pediatr Surg"},{"key":"10.1002\/hep.1840100520-BIB3","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/00000658-198710000-00001","volume":"206","author":"Busuttil","year":"1987","journal-title":"Ann Surg"},{"key":"10.1002\/hep.1840100520-BIB4","first-page":"3267","volume":"19","author":"Andrews","year":"1987","journal-title":"Transplant Proc"},{"key":"10.1002\/hep.1840100520-BIB5","year":"1986","unstructured":"Vital Statistics of the U.S. 1982. Mortality. Part A, B, Vol. 2. Hyattsville, MD, 1986: 186."},{"key":"10.1002\/hep.1840100520-BIB6","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0022-3476(87)80545-0","volume":"110","author":"Esquivel","year":"1987","journal-title":"J Pediatr"},{"key":"10.1002\/hep.1840100520-BIB7","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0022-3476(87)80548-6","volume":"110","author":"Lilly","year":"1987","journal-title":"J Pediatr"},{"key":"10.1002\/hep.1840100520-BIB8","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0022-3476(87)80105-1","volume":"111","author":"Malatack","year":"1987","journal-title":"J Pediatr"},{"key":"10.1002\/hep.1840100520-BIB9","first-page":"367","volume":"95","author":"Bismuth","year":"1984","journal-title":"Surgery"},{"key":"10.1002\/hep.1840100520-BIB10","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-3-642-82242-1_23","volume-title":"Chirurgisches Forun f. experim u. klinische Forschung Hrsg","author":"Broelsch","year":"1984","unstructured":", , et al. Orthotope transplantation von lebersegmenten bei kleinkindern mit gallengansatresien. In: ed. Chirurgisches Forun f. experim u. klinische Forschung Hrsg. Berlin: Springer, 1984: 105\u2013109."},{"key":"10.1002\/hep.1840100520-BIB11","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/00007890-198803000-00003","volume":"45","author":"Broelsch","year":"1988","journal-title":"Transplantation"},{"key":"10.1002\/hep.1840100520-BIB12","doi-asserted-by":"crossref","first-page":"107a","DOI":"10.1203\/00006450-198901000-00023","volume":"25","author":"Alonso","year":"1989","journal-title":"Pediatr Res"},{"key":"10.1002\/hep.1840100520-BIB13","doi-asserted-by":"crossref","first-page":"281a","DOI":"10.1203\/00006450-198704010-00686","volume":"21","author":"Whitington","year":"1987","journal-title":"Pediatr Res"},{"key":"10.1002\/hep.1840100520-BIB14","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/00000658-198810000-00003","volume":"208","author":"Broelsch","year":"1988","journal-title":"Ann Surg"},{"key":"10.1002\/hep.1840100520-BIB15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/978-94-011-6267-8_22","volume-title":"Organ preservation: basic and applied aspects","author":"Collins","year":"1982","unstructured":"Flush preservation. In: , , eds. Organ preservation: basic and applied aspects. Lancaster: MTP Press, 1982: 167\u2013177."},{"key":"10.1002\/hep.1840100520-BIB16","first-page":"617","volume":"1","author":"Kalayoglu","year":"1988","journal-title":"Lancet"},{"key":"10.1002\/hep.1840100520-BIB17","volume-title":"Le foie: \u00e9tudes anatomiques et chirurgicales","author":"Couinaud","year":"1957","unstructured":"Le foie: \u00e9tudes anatomiques et chirurgicales. Paris: Masson, 1957."},{"key":"10.1002\/hep.1840100520-BIB18","first-page":"143","volume":"1","author":"Emond","year":"1987","journal-title":"Clin Transplant"},{"key":"10.1002\/hep.1840100520-BIB19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","volume":"53","author":"Kaplan","year":"1959","journal-title":"J Am Stat Assoc"},{"key":"10.1002\/hep.1840100520-BIB20","first-page":"539","volume":"36","author":"Singer","year":"1988","journal-title":"Clin Res"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840100520","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198911000-00019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T15:27:42Z","timestamp":1738942062000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198911000-00019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1989]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840100520","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1989,11]]}}}