{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:10:33Z","timestamp":1792671033435,"version":"4.5.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":9374,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>This study describes a murine model of autoimmune hepatitis: experimental autoimmune hepatitis. Experimental autoimmune hepatitis could be induced most effectively in male C57BL\/6 mice by intraperitoneal immunization with the 100,000 <jats:italic toggle=\"yes\">g<\/jats:italic> superantant of syngeneic liver homogenate (S\u2013100) in complete Freund's adjuvant. BALB\/C and C3H mice were less susceptible than C57BL\/6 mice. Experimental autoimmune hepatitis could not be induced in Lewis rats. Intraperitoneal immunization was more effective than intramuscular or subcutaneous injections, and the amount of protein administered above a threshold was of little influence. A single intraperitoneal injection of S\u2013100 in complete Freund's adjuvant resulted in hepatitis of at least 6 mo duration. Histological changes were most marked 4 wk after disease induction. The histological findings were characterized mainly by perivascular inflammatory infiltrates and hepatocyte necroses. The histological changes were accompanied by biochemical evidence of liver cell death. Passive transfer of experimental autoimmune hepatitis with concanavalin. A-activated splenocytes was possible. Specific T\u2013cell reactivity against fractions of S\u2013100 could be demonstrated <jats:italic toggle=\"yes\">in vitro.<\/jats:italic> Thus experimental autoimmune hepatitis is a murine model of autoimmune hepatitis probably mediated by autoreactive T cells. It will allow studies of the pathogenesis of autoimmune hepatitis. (HEPATOLOGY 1990; 11: 24-30.)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840110106","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:03:52Z","timestamp":1172963032000},"page":"24-30","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":106,"title":["Experimental Autoimmune Hepatitis: Disease Induction, Time Course and T\u2013Cell Reactivity"],"prefix":"10.1097","volume":"11","author":[{"given":"Ansgar W.","family":"Lohse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Manns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Dienes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Hermann Meyer","family":"Zum B\u00fcschenfelde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irun R.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840110106-BIB1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1055\/s-2008-1040643","volume":"4","author":"Meyer zum B\u00fcschenfelde","year":"1984","journal-title":"Semin Liver Dis"},{"key":"10.1002\/hep.1840110106-BIB2","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1002\/hep.1840070631","volume":"7","author":"Maddrey","year":"1987","journal-title":"HEPATOLOGY"},{"key":"10.1002\/hep.1840110106-BIB3","first-page":"99","volume":"10","author":"Meyer zum B\u00fcschenfelde","year":"1982","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840110106-BIB4","first-page":"498","volume":"55","author":"Meyer zum B\u00fcschenfelde","year":"1974","journal-title":"Br J Exp Pathol"},{"key":"10.1002\/hep.1840110106-BIB5","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/0016-5085(83)90085-9","volume":"84","author":"Kuriki","year":"1983","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840110106-BIB6","first-page":"85","volume":"57","author":"Mori","year":"1984","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840110106-BIB7","first-page":"577","volume":"61","author":"Mori","year":"1985","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840110106-BIB8","first-page":"326","volume":"67","author":"Araki","year":"1987","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840110106-BIB9","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.4049\/jimmunol.131.5.2427","volume":"131","author":"Brusdelis","year":"1983","journal-title":"J Immunol"},{"key":"10.1002\/hep.1840110106-BIB10","first-page":"263","volume":"42","author":"Manns","year":"1980","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840110106-BIB11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-065X.1986.tb01161.x","volume":"94","author":"Cohen","year":"1986","journal-title":"Immunol Rev"},{"key":"10.1002\/hep.1840110106-BIB12","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1126\/science.2471264","volume":"244","author":"Lohse","year":"1989","journal-title":"Science"},{"key":"10.1002\/hep.1840110106-BIB13","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0140-6736(87)92024-1","volume":"1","author":"Manns","year":"1987","journal-title":"Lancet"},{"key":"10.1002\/hep.1840110106-BIB14","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1172\/JCI113949","volume":"83","author":"Manns","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840110106-BIB15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/jcla.1860020412","volume":"2","author":"Manns","year":"1988","journal-title":"J Clin Lab Anal"},{"key":"10.1002\/hep.1840110106-BIB16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0140-6736(86)90003-6","volume":"2","author":"Holoshitz","year":"1986","journal-title":"Lancet"},{"key":"10.1002\/hep.1840110106-BIB17","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0140-6736(88)90123-7","volume":"2","author":"Res","year":"1988","journal-title":"Lancet"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840110106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-199001000-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T15:23:27Z","timestamp":1738941807000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-199001000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840110106","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1990,1]]}}}