{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:10Z","timestamp":1760188870814,"version":"3.37.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":9374,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>A hamster model of schistosomiasis has provided the first opportunity to sequentially examine the early phases of the development of portal hypertension in a natural model of chronic liver disease.<\/jats:p>\n            <jats:p>Groups of hamsters were infected with 50 cercariae of <jats:italic toggle=\"yes\">Schistosoma mansoni<\/jats:italic> and underwent hemodynamic evaluation at intervals of 5, 8, 12 and 20 wk after infection. A progressive rise in intrahepatic resistance (from 4.0 \u00b1 0.4 to 8.4 \u00b1 1.0 mm Hg min. ml<jats:sup>-1<\/jats:sup>. gm liver weight [p &lt;0.01]) appeared to play a major role in the initial stages of evolving portal hypertension. A gradual decline in portal blood flow (from 2.1 \u00b1 0.3 to 1.3 \u00b1 0.1 ml. min<jats:sup>-1<\/jats:sup>gm<jats:sup>-1<\/jats:sup>liver weight [p &lt;0.01]) was only partially compensated for by an increase in hepatic arterial flow. Accordingly, by week 20, total hepatic blood flow decreased 23%. Liver weight that increased markedly between 5 and 12 wk after infection, as a result of the acute accumulation of obstructing granulomas, stabilized between wk 12 and 20, while a gradual but progressive rise in hepatic collagen content was seen. Portal pressure increased 75% during the study period.<\/jats:p>\n            <jats:p>Chronic examination of this natural model should help define the pathogenesis of the complications of portal hypertension and contribute to the basis for effective intervention in this disease process.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840110117","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:03:52Z","timestamp":1172963032000},"page":"98-104","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":27,"title":["Hemodynamic Mechanisms of Emerging Portal Hypertension Caused by Schistosomiasis in the Hamster"],"prefix":"10.1097","volume":"11","author":[{"given":"James S.","family":"Morgan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto 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