{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T04:13:30Z","timestamp":1742876010686,"version":"3.40.2"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":9315,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Hepatic transferrin receptors were studied in normal male rats at 1 to 59 wk after weaning, using immunohistochemical and biochemical techniques. The number of transferrin receptors measured and the intensity of the staining <jats:italic toggle=\"yes\">in situ<\/jats:italic> decreased rapidly during the first 10 wk of life and more slowly thereafter. Immunohisto\u2013chemistry further demonstrated changes in the topographical and (sub)cellular localization of the transferrin receptor. In the young rat livers, staining was almost exclusively present on hepatocytes in acinar zone 2 + 3 in a boneycomb to sinusoidal pattern. With aging, a panacinar heterogeneous and mainly sinusoidal staining of hepatocytes was more frequent. Kupffer cell positivity was more obvious as compared with the young rat livers. The observed changes in transferrin receptor expression may partly be explained by age\u2013dependent alterations in DNA synthesis and proliferative potential of the liver cells. A series of rats were iron loaded with carbonyl iron up to 39 wk and \u201cunloaded\u201d by administration of a normal diet during 20 wk. In these animals, serial histochemical studies showed predominantly parenchymal (7 to 14 wk), mixed parenchmal and reticuloendothelial (39 wk) and almost exclusive reticuloendothelial siderosis (59 wk). In the siderotic livers transferrin receptor numbers tended to be lower than in the controls with significant differences after 14 and 39 wk. Immunohistochemistry showed decreased parenchymal but increased reticuloendothelial transferrin receptor expression with iron load. After the period of unloading, parenchymal transferrin receptors were virtually absent despite the negligible siderosis of these cells. In contrast, siderotic reticuloendothelial cells were intesely positive. These findings support down\u2013regulation of parenchymal transferrin receptor resulting from iron storage. However, the positivity of siderotic reticuloendothelial cells and the absence of reemergence of parenchymal receptors in conditions of minimal parenchymal and prominent reticuloendothelial siderosis need further elucidation.(Hepatology 1990;11:416-427.)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840110313","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:16:36Z","timestamp":1172963796000},"page":"416-427","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":19,"title":["Transferrin Receptor Expression in Rat Liver: Immunohistochemical and Biochemical Analysis of the Effect of Age and Iron Storage"],"prefix":"10.1097","volume":"11","author":[{"given":"Raf","family":"Sciot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Verhoeven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"van Eyken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Cailleau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeer J.","family":"Desmet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840110313-BIB1","first-page":"43","volume":"6","author":"Jones","year":"1979","journal-title":"Progr Liver Dis"},{"key":"10.1002\/hep.1840110313-BIB2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1055\/s-2008-1063918","volume":"5","author":"Jones","year":"1985","journal-title":"Semin Liver Dis"},{"key":"10.1002\/hep.1840110313-BIB3","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/hep.1840010515","volume":"1","author":"Evans","year":"1981","journal-title":"HEPATOLOGY"},{"key":"10.1002\/hep.1840110313-BIB4","first-page":"99","volume":"8","author":"Steer","year":"1986","journal-title":"Prog Liver Dis"},{"key":"10.1002\/hep.1840110313-BIB5","first-page":"207","volume-title":"The liver: biology and pathobiology","author":"Forgac","year":"1988","unstructured":"Receptor-mediated endocytosis. In: , , , , eds. The liver: biology and pathobiology. New York: Raven Press, 1988; 207\u2013225."},{"key":"10.1002\/hep.1840110313-BIB6","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1152\/physrev.1987.67.2.520","volume":"67","author":"Huebers","year":"1987","journal-title":"Physiol Rev"},{"key":"10.1002\/hep.1840110313-BIB7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1055\/s-2008-1041769","volume":"4","author":"Bacon","year":"1984","journal-title":"Semin Liver Dis"},{"key":"10.1002\/hep.1840110313-BIB8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1749-6632.1988.tb55493.x","volume":"526","author":"Morgan","year":"1988","journal-title":"Ann NY Acad Sci"},{"key":"10.1002\/hep.1840110313-BIB9","first-page":"2810","volume":"45","author":"Morgan","year":"1986","journal-title":"Fed Proc"},{"key":"10.1002\/hep.1840110313-BIB10","first-page":"131","volume":"13","author":"Seligman","year":"1983","journal-title":"Prog Hematol"},{"key":"10.1002\/hep.1840110313-BIB11","first-page":"535","volume-title":"The liver: biology and pathobiology","author":"Young","year":"1988","unstructured":". The liver and iron. In: , , , , eds. The liver: biology and pathobiology. 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Age related perturbations of vesicular transport and ligand processing in hepatocytes. In: , , , eds. Aging in liver and gastro-intestinal tract. Lancaster: MTP Press Limited, 1988: 181\u2013190."},{"key":"10.1002\/hep.1840110313-BIB37","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1002\/hep.1840080609","volume":"8","author":"Van der Sluijs","year":"1988","journal-title":"HEPATOLOGY"},{"key":"10.1002\/hep.1840110313-BIB38","first-page":"555","volume":"57","author":"Park","year":"1987","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840110313-BIB39","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/BF02890245","volume":"53","author":"Iancu","year":"1987","journal-title":"Virchows Arch [Cell Pathol]"},{"key":"10.1002\/hep.1840110313-BIB40","first-page":"181","volume-title":"Pathology of the liver","author":"Searle","year":"1987","unstructured":", , . Iron storage disease. In: , , eds. Pathology of the liver. 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