{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:17Z","timestamp":1761058637322,"version":"3.37.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":9284,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,4]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Galactosamine hydrochloride induces liver disease in tats that morphologically resembles drug\u2013induced hepatitis in man. In this study we analyzed the character of the inflammatory reaction following the toxic damage resulting from the administration of galactosamine hydrochloride using a broad panel of mono clonal antibodies to lymphocyte subsets and macrophages. Fat\u2013storing cells were identified with a polyclonal anti\u2013desmin antibody. Cellular proliferation was assessed by labeling S\u2013phase cells with the thymidine analog bronmodeoxyuridine. Injection of galactosamine hydrochloride was associated with conspicuous hepatocyte necrosis and parenchymal granulocyte influx in the first 24 hr. thereafter, mononuclear inflammatory cells predominated, mainly T lymphocytes and macorphages, with maximal numbers at 48 hr. The majority of T lymphocytes were CD8\u2013positive cells and were located in the portal tracts and parenchyma. CD4 positive T cells were scarce and confined to the portal tracts. Proliferation of fat\u2013storing cells paralleled hepatocyte regeneration with maximal values after 48 to 72 hr.<\/jats:p>\n            <jats:p>The temporal relationship between infiltrating mononuclear cells, mainly T lymphocytes of CD8 phenotype and macrophages, fat\u2013storing cell proliferation and hepatic gegeneration suggests pathophysiological interactions between these cell types in liver injury in the rat after galactosamine hydrochloride administration.(HEPATOLOGY 1990; 11:622:627.)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840110415","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:15:53Z","timestamp":1172963753000},"page":"622-627","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":32,"title":["Immunolpathology of Acute Galactosamine Hepatitis in Rats"],"prefix":"10.1097","volume":"11","author":[{"given":"Meike A.","family":"Jonker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freke W.J.","family":"Dijkhuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans G.M.","family":"Kroese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Machiel J.","family":"Hardonk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joris","family":"Grond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840110415-BIB1","first-page":"183","volume-title":"Progress of liver disease","volume":"4","author":"Decker","year":"1972","unstructured":". 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