{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:17Z","timestamp":1761058637740,"version":"3.37.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":9284,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,4]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Adult male Sprague\u2013Dawley rats with streptozotocin\u2013induced diabetes (6 to 8 wk duration), treated or untreated with insulin, were studied with two aims: (a) to ascertain whether protracted diabetes in the rat is associated with changes in circulating plasma protein levels analogous to those reported in human diabetic patients with clinical evidence of complications; (b) to evaluate the effects of experimental diabetes on the net cumulative biosynthesis of 10 specific plasma proteins by the isolated liver, perfused for 24 hr.<\/jats:p>\n            <jats:p>Samples of liver donor plasma and samples of perfusate were analyzed by single radial immunodiffusion or by rocket immunoelectrophoresis for albumin, \u03b1<jats:sub>1<\/jats:sub>\u2013macroglobulin and the acute phase glycoproteins: fibrinogen, \u03b1<jats:sub>1<\/jats:sub>\u2013acid glycoprotein (Darcy), \u03b1<jats:sub>1<\/jats:sub>, acid glycoprotein (Kawasaki), haptoglobin, \u03b1<jats:sub>2<\/jats:sub>\u2013(acute phase) globulin, hemopexin, C3\u2013complement and ceruloplasmin.<\/jats:p>\n            <jats:p>Diabetes (6 to 8 wk), untreated with insulin, resulted in significantly increased liver donor plasma levels of \u03b1<jats:sub>1<\/jats:sub>\u2013acid glycoprotein (Darcy) and \u03b1<jats:sub>1<\/jats:sub>\u2013acid glycoprotein (Kawasaki); plasma levels of hemopexin and of C3 decreased to 75% and 30% of normal, respectively. Insulin treatment of diabetic liver donors for 6 to 8 wk prevented the increase in \u03b1<jats:sub>1<\/jats:sub>\u2013acid glycoprotein (Darcy) and \u03b1<jats:sub>1<\/jats:sub>\u2013acid glycoprotein (Kawasaki) and minimized the decrease in C3 to 75% of normal.<\/jats:p>\n            <jats:p>Perfused livers from untreated diabetic rats (6 to 8 wk) showed slightly decreased cumulative synthesis and secretion of \u03b1<jats:sub>1<\/jats:sub>\u2013acid glycoprotein (Darcy); however, synthesis of albumin was reduced to 35% of normal and that of eight glycoproteins ranged from 25% of normal and that of eight glycoproteins renged from 25% of normal (fibrinogen) to 12% of normal (C3). The striking <jats:italic toggle=\"yes\">in vitro<\/jats:italic> induction of increased synthesis of acute\u2013phase proteins by cortisol plus insulin in the isolated perfused normalliver was in contrast to the severely attenuated induction in perfused livers of untreated diabetic rats, which ranges from 50% of normal for \u03b1<jats:sub>1<\/jats:sub>\u2013acid glycoprotein (Darcy) to 5% of normal (C3).<\/jats:p>\n            <jats:p>Severely negative perfusate nitrogen balance and impaired glucose utilization by perfused untreated diabetic livers contrasted with positive nitrogen balance and good glucose utilization of normal livers in response to insulin plus cortisol. The plasma protein synthetic capacity and the <jats:italic toggle=\"yes\">in vitro<\/jats:italic> response to insulin plus cortisol of perfused livers from insulin\u2013treated diabetic rats were normal for seven of the proteins but moderately decreased for albumin, haptoglobin and C3.(HEPATOLOGY 1990; 11:635\u2013645.)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840110417","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:15:53Z","timestamp":1172963753000},"page":"635-645","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Effects of Streptozotocin Diabetes in the Rat on Blood Levels of Ten Specific Plasma Proteins and on Their Net Biosynthesis by the Isolated Perfused Liver"],"prefix":"10.1097","volume":"11","author":[{"given":"Leon L.","family":"Miller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna Eddy","family":"Treat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Fridd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drusilla","family":"Wemett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840110417-BIB1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/BF01241033","volume":"4","author":"Cleve","year":"1968","journal-title":"Diabetologia"},{"key":"10.1002\/hep.1840110417-BIB2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1530\/acta.0.0550537","volume":"55","author":"Ganrot","year":"1967","journal-title":"Acta Endocrinol (Copenh)"},{"key":"10.1002\/hep.1840110417-BIB3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF00422091","volume":"12","author":"Jonsson","year":"1976","journal-title":"Diabetologia"},{"key":"10.1002\/hep.1840110417-BIB4","first-page":"12760","volume":"21","author":"M\u00fcller","year":"1970","journal-title":"Klin Wochenschr"},{"key":"10.1002\/hep.1840110417-BIB5","first-page":"1641","volume":"18","author":"Solerte","year":"1986","journal-title":"Transplant Proc"},{"key":"10.1002\/hep.1840110417-BIB6","doi-asserted-by":"crossref","first-page":"5879","DOI":"10.1073\/pnas.75.12.5879","volume":"75","author":"Peavy","year":"1978","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hep.1840110417-BIB7","doi-asserted-by":"crossref","first-page":"e656","DOI":"10.1152\/ajpendo.1985.248.6.E656","volume":"248","author":"Peavy","year":"1985","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1002\/hep.1840110417-BIB8","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/S0021-9258(18)33203-4","volume":"258","author":"Jefferson","year":"1983","journal-title":"J Biol Chem"},{"key":"10.1002\/hep.1840110417-BIB9","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1016\/S0021-9258(20)81337-4","volume":"235","author":"Green","year":"1960","journal-title":"J Biol Chem"},{"key":"10.1002\/hep.1840110417-BIB10","doi-asserted-by":"crossref","first-page":"6134","DOI":"10.1016\/S0021-9258(18)63516-1","volume":"244","author":"John","year":"1969","journal-title":"J Biol Chem"},{"key":"10.1002\/hep.1840110417-BIB11","first-page":"461","volume":"23","author":"Miller","year":"1976","journal-title":"Prot Biol Fluids"},{"key":"10.1002\/hep.1840110417-BIB12","first-page":"133","volume-title":"Plasma protein secretion by the liver","author":"Miller","year":"1983","unstructured":"Role of known hormones in In: , , eds. Plasma protein secretion by the liver. London, New York: Academic Press, 1983: 133\u2013152."},{"key":"10.1002\/hep.1840110417-BIB13","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3181\/00379727-122-31180","volume":"122","author":"Kumaresan","year":"1966","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1002\/hep.1840110417-BIB14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/jez.1401760410","volume":"176","author":"Schedl","year":"1971","journal-title":"J Exp Zool"},{"key":"10.1002\/hep.1840110417-BIB15","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1210\/endo-108-4-1265","volume":"108","author":"Miller","year":"1981","journal-title":"Endocrinology"},{"key":"10.1002\/hep.1840110417-BIB16","first-page":"11","volume-title":"Isolated liver perfusion and its application","author":"Miller","year":"1973","unstructured":"Technique of isolated rat liver perfusion. In: , , eds. Isolated liver perfusion and its application. 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Direct effects of in In: ed. Insulin Action. Ch XIX, New York: Academic Press, 1972; 487\u2013507."},{"key":"10.1002\/hep.1840110417-BIB28","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1084\/jem.94.5.431","volume":"94","author":"Miller","year":"1951","journal-title":"J Exp Med"},{"key":"10.1002\/hep.1840110417-BIB29","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0003-9861(83)90028-0","volume":"225","author":"Murtiashaw","year":"1983","journal-title":"Archiv Biochem Biophys"},{"key":"10.1002\/hep.1840110417-BIB30","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/B978-0-12-452803-1.50013-6","volume-title":"Biochemical Actions of Hormones","volume":"3","author":"Miller","year":"1975","unstructured":". Regulation of net biosynthesis of albumin, fibrinogen, \u03b11-acid glycoprotein, \u03b12-(acute phase) globulin, and haptoglobin by the direct action of hormones on the isolated perfused liver. In: ed. Biochemical Actions of Hormones, Vol. 3. 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