{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T07:39:04Z","timestamp":1770536344114,"version":"3.49.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":9284,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,4]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Mallory bodies are characteristic morphological features of alcoholic hepatitis in man and can be produced in the mouse by chronic griseofulvin intoxication. The appearance of Mallory bodies in hepatocytes is associated with derangement of the cytokeratin intermediate filament cytoskeleton, at least as revealed by immunofluorescence and suggested by immunoelectron microscopy. Immunohistochemical studies were performed to answer the question whether Mallory body formation and cytoskeleton alterations finally lead to cell death or are reversible phenomena. Chronically griseofulvin\u2013intoxicated mice killed at different stages of recovery on a normal diet served as experimental animals. It could be shown that (a) Mallory bodies are very durable structures and are found for up to 6 mo after griseofulvin withdrawal as a result of persistence and neoformation; (b) new Mallory bodies can appear even several months after cessation of griseofulvin feeding; (c) Mallory body formation and cytoskeletal changes by themselves do not lead to irreversible cell damage; (d) the cytoskeletal changes are reversible within 7 mo after griseofulvin withdrawal; (e) a dissociation between disappearance of Mallory bodies and restoration of a regularly immunostained cytoplasmic cytokeratin meshwork is observed.(HEPATOLOGY 1990; 11:652\u2013661.)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840110419","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:15:53Z","timestamp":1172963753000},"page":"652-661","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":27,"title":["Fate of Mallory Body\u2013Containing Hepatocytes: Disappearance of Mallory Bodies and Restoration of the Hepatocytic Intermediate Filament Cytoskeleton After Drug Withdrawal in the Griseofulvin\u2013Treated Mouse"],"prefix":"10.1097","volume":"11","author":[{"given":"Kurt","family":"Zatloukal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerlinde","family":"Spurej","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Rainer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Lackinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Denk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840110419-BIB1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0092-8674(82)90400-7","volume":"31","author":"Moll","year":"1982","journal-title":"Cell"},{"key":"10.1002\/hep.1840110419-BIB2","first-page":"237","volume-title":"Progress in liver diseases","author":"Denk","year":"1986","unstructured":", . Pathology of the cytoskeleton of hepatocytes. In: , eds. Progress in liver diseases. Vol VIII. New York: Grune & Stratton, 1986: 237\u2013251."},{"key":"10.1002\/hep.1840110419-BIB3","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1432-0436.1986.tb00788.x","volume":"30","author":"Magin","year":"1986","journal-title":"Differentiation"},{"key":"10.1002\/hep.1840110419-BIB4","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1432-0436.1986.tb00787.x","volume":"30","author":"Romano","year":"1986","journal-title":"Differentiation"},{"key":"10.1002\/hep.1840110419-BIB5","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/302794a0","volume":"302","author":"Steinert","year":"1983","journal-title":"Nature"},{"key":"10.1002\/hep.1840110419-BIB6","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0092-8674(85)90098-4","volume":"42","author":"Steinert","year":"1985","journal-title":"Cell"},{"key":"10.1002\/hep.1840110419-BIB7","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1083\/jcb.90.1.222","volume":"90","author":"Schliwa","year":"1981","journal-title":"J Cell Biol"},{"key":"10.1002\/hep.1840110419-BIB8","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-70230-3","volume-title":"Intermediate filaments: a review","author":"Traub","year":"1985","unstructured":"ed. Intermediate filaments: a review. New York: Springer-Verlag, 1985."},{"key":"10.1002\/hep.1840110419-BIB9","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1083\/jcb.79.2.427","volume":"79","author":"Drochmans","year":"1978","journal-title":"J Cell Biol"},{"key":"10.1002\/hep.1840110419-BIB10","first-page":"361","volume":"110","author":"Rungger-Br\u00e4ndle","year":"1983","journal-title":"Am J Pathol"},{"key":"10.1002\/hep.1840110419-BIB11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1600-0676.1982.tb00194.x","volume":"2","author":"Denk","year":"1982","journal-title":"Liver"},{"key":"10.1002\/hep.1840110419-BIB12","first-page":"773","volume":"32","author":"Denk","year":"1975","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840110419-BIB13","first-page":"557","volume-title":"Progress in liver disease","author":"French","year":"1979","unstructured":". Alcoholic hepatitis: clinical, morphologic, pathogenic, and therapeutic aspects. In: , eds. Progress in liver disease. Vol VI. New York: Grune & Stratton, 1979: 557\u2013579."},{"key":"10.1002\/hep.1840110419-BIB14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1055\/s-2008-1040605","volume":"6","author":"MacSween","year":"1986","journal-title":"Semin Liver Dis"},{"key":"10.1002\/hep.1840110419-BIB15","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0016-5085(87)90861-4","volume":"92","author":"Orrego","year":"1987","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840110419-BIB16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/hep.1840010103","volume":"1","author":"Denk","year":"1981","journal-title":"HEPATOLOGY"},{"key":"10.1002\/hep.1840110419-BIB17","first-page":"491","volume":"45","author":"Kimoff","year":"1981","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840110419-BIB18","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1136\/gut.27.7.765","volume":"27","author":"Barbatis","year":"1986","journal-title":"Gut"},{"key":"10.1002\/hep.1840110419-BIB19","first-page":"534","volume":"53","author":"Okanoue","year":"1985","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840110419-BIB20","first-page":"543","volume":"54","author":"Hazan","year":"1986","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840110419-BIB21","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1083\/jcb.101.4.1442","volume":"101","author":"Cowin","year":"1985","journal-title":"J Cell Biol"},{"key":"10.1002\/hep.1840110419-BIB22","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0014-4827(85)90500-2","volume":"161","author":"Denk","year":"1985","journal-title":"Exp Cell Res"},{"key":"10.1002\/hep.1840110419-BIB23","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/ar.1091710302","volume":"171","author":"Luft","year":"1971","journal-title":"Anat Rec"},{"key":"10.1002\/hep.1840110419-BIB24","first-page":"241","volume":"23","author":"Denk","year":"1981","journal-title":"Eur J Cell Biol"},{"key":"10.1002\/hep.1840110419-BIB25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0014-4827(81)90234-2","volume":"131","author":"Franke","year":"1981","journal-title":"Exp Cell Res"},{"key":"10.1002\/hep.1840110419-BIB26","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1002\/hep.1840110419-BIB27","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1002\/hep.1840110419-BIB28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF00712737","volume":"411","author":"Franke","year":"1987","journal-title":"Virchows Arch [A]"},{"key":"10.1002\/hep.1840110419-BIB29","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1083\/jcb.106.5.1635","volume":"106","author":"Bosch","year":"1988","journal-title":"J Cell Biol"},{"key":"10.1002\/hep.1840110419-BIB30","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1083\/jcb.98.6.1973","volume":"98","author":"Fey","year":"1984","journal-title":"J Cell Biol"},{"key":"10.1002\/hep.1840110419-BIB31","first-page":"336","volume":"47","author":"Irie","year":"1982","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840110419-BIB32","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/hep.1840070608","volume":"7","author":"Katsuma","year":"1987","journal-title":"HEPATOLOGY"},{"key":"10.1002\/hep.1840110419-BIB33","first-page":"578","volume":"133","author":"Ohta","year":"1988","journal-title":"Am J Pathol"},{"key":"10.1002\/hep.1840110419-BIB34","first-page":"134","volume":"113","author":"Lai","year":"1989","journal-title":"Arch Pathol Lab Med"},{"key":"10.1002\/hep.1840110419-BIB35","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.bi.57.070188.003113","volume":"57","author":"Steinert","year":"1988","journal-title":"Annu Rev Biochem"},{"key":"10.1002\/hep.1840110419-BIB36","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1083\/jcb.102.2.560","volume":"102","author":"Bologna","year":"1986","journal-title":"J Cell Biol"},{"key":"10.1002\/hep.1840110419-BIB37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0309-1651(83)90098-X","volume":"7","author":"Schiller","year":"1983","journal-title":"Cell Biol Int Rep"},{"key":"10.1002\/hep.1840110419-BIB38","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0022-5320(71)80116-8","volume":"36","author":"Wolff","year":"1971","journal-title":"J Ultrastruct Mol Struct Res"},{"key":"10.1002\/hep.1840110419-BIB39","doi-asserted-by":"crossref","first-page":"7929","DOI":"10.1073\/pnas.82.23.7929","volume":"82","author":"Soellner","year":"1985","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840110419","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-199004000-00018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T15:34:33Z","timestamp":1738942473000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-199004000-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,4]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840110419","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1990,4]]}}}