{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:34:33Z","timestamp":1752550473127,"version":"3.37.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":9254,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Hypercitrullinemia (adult type), believed to be one of the hereditary urea cycle disorders, is known to be complicated by hepatocellular carcinoma at a high incidence (approximately 14%). Weinvestigated the relationship between this hypercitrullinemia and he\u2013patocarcinogenesis. After the addition of citrulline, incorporation of tritiated thymidine into primary cultured hepatocytes of adult rat increased in a dose\u2013dependent fashion in the range of 0.1 to 5 mmol\/L. The citrulline\u2013added group also showed significant in\u2013crease in ornithine and polyamine contents in hepatpcytes. The incidence of epithelial cell foci in the <jats:italic toggle=\"yes\">in vivo\u2013in vitro<\/jats:italic> tumor promotion analyzing system significantly rose in the group maintained with mmol\/L citrulline and in the group maintained with 1.5 mmol\/L phenobarbital. These findings suggest the possiblility that citrulline has a promotion effect on hepatocyte proliferation and that at high concentra\u2013tions it plays the role of a hepatocarcinogenesis pro\u2013moter.(HEPATOLOGY 1990; 11:819\u2013823.)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840110517","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:27:36Z","timestamp":1172964456000},"page":"819-823","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":16,"title":["Promoting Effect of Citrulline in Hepatocarconogenesis: Possbile Mechanism in Hypercitrullinemia"],"prefix":"10.1097","volume":"11","author":[{"given":"Maski","family":"Nakayama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyki","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomofumi","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadasu","family":"Tsujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840110517-BIB1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0140-6736(62)91135-2","volume":"1","author":"MacMurry","year":"1962","journal-title":"Lancet"},{"key":"10.1002\/hep.1840110517-BIB2","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/BF02777374","volume":"11","author":"Tsujii","year":"1976","journal-title":"Gastroenterol Jpn"},{"key":"10.1002\/hep.1840110517-BIB3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF01819306","volume":"8","author":"Saheki","year":"1985","journal-title":"J Inherit Metab Dis"},{"key":"10.1002\/hep.1840110517-BIB4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0009-8981(81)90318-1","volume":"109","author":"Saheki","year":"1981","journal-title":"Clin Chim Acta"},{"key":"10.1002\/hep.1840110517-BIB5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/978-1-4757-6903-6_9","volume":"153","author":"Saheki","year":"1982","journal-title":"Adv Exp Med Biol"},{"key":"10.1002\/hep.1840110517-BIB6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3164\/jcbn.1.129","volume":"1","author":"Saheki","year":"1986","journal-title":"J Clin Biochemi Nutr"},{"key":"10.1002\/hep.1840110517-BIB7","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1093\/oxfordjournals.jbchem.a132207","volume":"84","author":"Tanaka","year":"1978","journal-title":"J Biochem"},{"key":"10.1002\/hep.1840110517-BIB8","first-page":"2363","volume":"43","author":"Kubota","year":"1983","journal-title":"Cancer Res"},{"key":"10.1002\/hep.1840110517-BIB9","first-page":"747","volume":"71","author":"Kitagawa","year":"1980","journal-title":"Jpn Cancer Res (Gann)"},{"key":"10.1002\/hep.1840110517-BIB10","first-page":"1318","volume":"46","author":"Francavilla","year":"1986","journal-title":"Cancer Res"},{"key":"10.1002\/hep.1840110517-BIB11","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/jcp.1041080309","volume":"108","author":"McGowan","year":"1981","journal-title":"J Cell Physiol"},{"key":"10.1002\/hep.1840110517-BIB12","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/0006-291X(84)91253-1","volume":"122","author":"Nakamura","year":"1984","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/hep.1840110517-BIB13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0014-4827(81)90172-5","volume":"135","author":"Tomita","year":"1981","journal-title":"Exp Cell Res"},{"key":"10.1002\/hep.1840110517-BIB14","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/0006-291X(84)91173-2","volume":"122","author":"Nakamura","year":"1984","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/hep.1840110517-BIB15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF02620953","volume":"21","author":"Houck","year":"1985","journal-title":"In Vitro Cell Dev Biol"},{"key":"10.1002\/hep.1840110517-BIB16","first-page":"131","volume":"43","author":"McGowan","year":"1984","journal-title":"Fed Proc"},{"key":"10.1002\/hep.1840110517-BIB17","volume-title":"Introduction to the polyamines","author":"Cohen","year":"1971","unstructured":"Introduction to the polyamines. 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