{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T21:41:54Z","timestamp":1773178914169,"version":"3.50.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":9254,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The files of patients who underwent emergency endoscopy in a 2\u2013yr period (January 1985 to January 1987) in the Heinz\u2013Kalk Hospital were analyzed to establish the frequency, significance and therapy of the Mallory\u2013Weiss syndrome associated with portal hypertension, an association observed in 55 of 339 patients (16.2%). Portal hypertension was caused by cirrhosis in 53 patients and by a prehepatic block in two patients. For 21 of these patients (37%) with portal hypertension, Mallory\u2013Weiss syndrome was the first bleeding manifestation. They numbered 6.2% of the whole population. In the remaining 34 patients (63%) sclerotherapy treatment had been previously performed. No lesions that suggested peptic esophagitis were seen in these 55 patients, although in 25 of them (45.4%) a gastroesophageal reflux was observed. The frequency of bleeding from a Mallory\u2013 Weiss tear was significantly higher in patients with advanced liver disease, particularly with Child\u2013Pugh classifications C and B. In patients with prehepatic block, a hemorrhage from a Mallory\u2013Weiss tear may occur, but the frequency is significantly lower than it is in patients with cirrhosis. The bleeding tear was treated by transendoscopic esophageal and cardial wall sclerosis (paravariceal technique) and was, in all cases, successfully controlled. Mallory\u2013Weiss syndrome is observed more frequently in patients with portal hypertension and cirrhosis. Gastroesophageal reflux apparently does not play a major role in the pathogenesis of this syndrome. It may simply be the manifestation of an abnormal gastroesophageal function. Mallory\u2013Weiss syndrome can also be observed as a cause of rebleeding in patients treated with chronic sclerotherapy. Paravariceal endoscopic sclerotherapy is apparently the treatment of first choice to stop hemorrhage.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840110525","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:27:36Z","timestamp":1172964456000},"page":"879-883","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":28,"title":["Frequency, Significance and Therapy of the Mallory\u2013Weiss Syndrome in Patients With Portal Hypertension"],"prefix":"10.1097","volume":"11","author":[{"given":"Karl J.","family":"Paquet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Mercado-Diaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johann F.","family":"Kalk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840110525-BIB1","first-page":"72","volume":"24","author":"Quincke","year":"1879","journal-title":"Arch Klin Med"},{"key":"10.1002\/hep.1840110525-BIB2","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/00000441-192910000-00005","volume":"178","author":"Mallory","year":"1929","journal-title":"Am J Med Sci"},{"key":"10.1002\/hep.1840110525-BIB3","first-page":"423","volume-title":"Surgery of the stomach and duodenum","author":"Donahue","year":"1986","unstructured":". 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