{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:07:51Z","timestamp":1792145271864,"version":"4.4.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":9223,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,6]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>A survey of Japanese autopsy cases of primary biliary cirrhosis disclosed that hepatocellular carcinoma is apparently becoming a better recognized complication of the advanced stage of primary biliary cirrhosis. Six autopsy cases (five women and one man) of primary biliary cirrhosis associated with hepatocellular carcinoma were obtained from several Japanese institutions and examined. All cases were in an established cirrhotic stage of primary biliary cirrhosis. Hepatocelluar carcinoma was incidentally found at autopsy in four cases and, in these, the carcinomas were small in size and number. The other two cases showed advanced hepatocellular carcinoma and one case showed extrahepatic metastasis. Histologically, all cases showed well\u2013differentiated hepatocellular carcinomas. Fatty changes or bile plugs were frequently seen within the tumors. Mallory body clusters and focal deposition of copper\u2013binding protein were consistently found in cirrhotic liver tissues and also in the carcinoma tissues of almost all cases. The presence of atypical adenomatous hyperplasia in the peripheries of some carcinomas suggested that hepatocellular carcinoma in primary biliary cirrhosis may evolve through multiple steps.(HEPATOLOGY 1990;11:1010\u20131016.).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840110616","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:35:56Z","timestamp":1172964956000},"page":"1010-1016","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":43,"title":["Hepatocellular Carcinoma in Primary Biliary Cirrhosis: An Autopsy Study"],"prefix":"10.1097","volume":"11","author":[{"given":"Yasuni","family":"Nakanuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Terada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Doishita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Miwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840110616-BIB1","first-page":"107","volume-title":"Hepatocellular carcinoma","author":"Peters","year":"1976","unstructured":"Pathology of hepatocellular carcinoma. In: , eds. Hepatocellular carcinoma. New York, London, Sydney, Toronto: John Wiley & Sons, Inc. 1976: 107\u2013168."},{"key":"10.1002\/hep.1840110616-BIB2","first-page":"4967","volume":"47","author":"Okuda","year":"1987","journal-title":"Cancer Res"},{"key":"10.1002\/hep.1840110616-BIB3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2957\/kanzo.27.497","volume":"27","author":"Sakaeda","year":"1986","journal-title":"Acta Hepatol Jap"},{"key":"10.1002\/hep.1840110616-BIB4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1136\/gut.20.3.255","volume":"20","author":"Krasner","year":"1979","journal-title":"Gut"},{"key":"10.1002\/hep.1840110616-BIB5","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/0016-5085(84)90540-7","volume":"87","author":"Melia","year":"1984","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840110616-BIB6","first-page":"418","volume":"84","author":"Teranda","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"10.1002\/hep.1840110616-BIB7","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/00004836-198510000-00016","volume":"7","author":"Gluskin","year":"1985","journal-title":"J Clin Gastroenterol"},{"key":"10.1002\/hep.1840110616-BIB8","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1002\/hep.1840080348","volume":"8","author":"Hadziyannis","year":"1988","journal-title":"HEPATOLOGY"},{"key":"10.1002\/hep.1840110616-BIB9","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/1097-0142(19890715)64:2<455::AID-CNCR2820640219>3.0.CO;2-C","volume":"64","author":"Merato","year":"1989","journal-title":"Cancer"},{"key":"10.1002\/hep.1840110616-BIB10","volume-title":"Annual of the pathological autopsy cases in Japan. Vol 20, January to December, 1977 through Vol. 30 January to December","author":"The Japanese Pathological Society.","year":"1977\u20131987","unstructured":"The Japanese Pathological Society. Annual of the pathological autopsy cases in Japan. Vol 20, January to December, 1977 through Vol. 30 January to December, 1977\u20131987 Tokyo: Ninji Kai Corp."},{"key":"10.1002\/hep.1840110616-BIB11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF01102738","volume":"382","author":"Nakanuma","year":"1979","journal-title":"Virchow Archiv [A]"},{"key":"10.1002\/hep.1840110616-BIB12","first-page":"506","volume":"30","author":"Eggel","year":"1901","journal-title":"Beitr Pathol Anat"},{"key":"10.1002\/hep.1840110616-BIB13","first-page":"19","volume":"20","author":"Gibson","year":"1978","journal-title":"Genoa World Health Organization"},{"key":"10.1002\/hep.1840110616-BIB14","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/1097-0142(195405)7:3<462::AID-CNCR2820070308>3.0.CO;2-E","volume":"7","author":"Edmondson","year":"1954","journal-title":"Cancer"},{"key":"10.1002\/hep.1840110616-BIB15","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0046-8177(82)80272-4","volume":"13","author":"Nakashima","year":"1982","journal-title":"Hum Pathol"},{"key":"10.1002\/hep.1840110616-BIB16","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/S0016-5085(88)80093-3","volume":"95","author":"Tsuda","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840110616-BIB17","author":"Nakanuma","year":"1990","unstructured":", , , , , . \u201cAtypical adenomatous hyperplasia\u201d in liver cirrhosis in humans: low grade hepatocellular carcinoma or borderline lesion. Histopathology 1990 [In press.]"},{"key":"10.1002\/hep.1840110616-BIB18","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0016-5085(86)90458-0","volume":"91","author":"Arakawa","year":"1986","journal-title":"Gastroenteroloogy"},{"key":"10.1002\/hep.1840110616-BIB19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/path.1711580107","volume":"158","author":"Grigioni","year":"1989","journal-title":"J Pathol"},{"key":"10.1002\/hep.1840110616-BIB20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/1097-0142(19880101)61:1<99::AID-CNCR2820610117>3.0.CO;2-U","volume":"61","author":"Furuya","year":"1988","journal-title":"Cancer"},{"key":"10.1002\/hep.1840110616-BIB21","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/0016-5085(78)90120-8","volume":"75","author":"Nakanuma","year":"1978","journal-title":"Jap J Gastroenterol"},{"key":"10.1002\/hep.1840110616-BIB22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1600-0676.1984.tb00914.x","volume":"4","author":"Ludwig","year":"1984","journal-title":"Liver"},{"key":"10.1002\/hep.1840110616-BIB23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/1097-0142(19860101)57:1<81::AID-CNCR2820570117>3.0.CO;2-4","volume":"57","author":"Nakanuma","year":"1986","journal-title":"Cancer"},{"key":"10.1002\/hep.1840110616-BIB24","first-page":"231","volume":"37","author":"Haratake","year":"1987","journal-title":"Acta Pathol Jpn"},{"key":"10.1002\/hep.1840110616-BIB25","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1600-0676.1988.tb01010.x","volume":"6","author":"Nakanuma","year":"1988","journal-title":"Liver"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840110616","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-199006000-00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T15:45:00Z","timestamp":1738943100000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-199006000-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1990]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840110616","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1990,6]]}}}