{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:10:38Z","timestamp":1790791838933,"version":"4.1.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":9040,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,12]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>To examine the effect of liver transplantation on the respiratory and cardiovascular functions, ventilation\/perfusion relationships were determined by multiple inert gas elimination technique in six patients with end-stage liver disease 1 to 19 mo before and 2 to 6 mo after liver transplantation. Cardiac output and pulmonary vascular pressures were measured after catheterization of the pulmonary artery. All patients had normal spirometry and chest x-ray films before transplantation.<\/jats:p>\n            <jats:p>PaO<jats:sub>2<\/jats:sub> before transplantation was 78.8 \u00b1 7.4 mm Hg (range = 51.8 to 102.8 mm Hg). All patients had perfusion of poorly ventilated lung regions (low ventilation\/perfusion relationships) varying from 3% to 19% of cardiac output (mean = 8.5% \u00b1 2.4% of cardiac output) and two patients had intrapulmonary shunting (3% and 20% of cardiac output). Measured and calculated PaI<jats:sub>2<\/jats:sub> agreed closely, indicating absence of pulmonary diffusion abnormality, as well as of extrapulmonary shunting. After transplantation, PaO<jats:sub>2<\/jats:sub> normalized in all patients, and both shunting and low ventilation\/perfusion relationships disappeared. Cardiac output decreased from 9.1 \u00b1 1.4 to 6.6 \u00b1 0.5 L\/min (p &lt; 0.05), and the pulmonary vascular resistance increased from 0.69 \u00b1 0.14 to 1.64 \u00b1 0.43 mm Hg\/L\/min (p &lt; 0.05). The systemic vascular resistance also increased (before = 8.7 \u00b1 1.0; after = 15.3 \u00b1 1.1 mm Hg\/L\/min; p &lt; 0.001).<\/jats:p>\n            <jats:p>Normalization of respiratory and cardiovascular alterations, after liver transplantation, in patients with end-stage liver disease indicates that these changes have a direct functional relationship to the diseased liver. It is hypothesized that this is part of a \u201chepatopulmonary syndrome,\u201d which in similarity to the hepatorenal syndrome disappears with improved liver function. (HEPATOLOGY 1990;12:1350-1357).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840120616","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:41:22Z","timestamp":1172965282000},"page":"1350-1357","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":107,"title":["Normalization of ventilation\/perfusion relationships after liver transplantation in patients with decompensated cirrhosis: Evidence for a hepatopulmonary syndrome"],"prefix":"10.1097","volume":"12","author":[{"given":"Ljusk Siw","family":"Eriksson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"S\u00f6derman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-G\u00f6ran","family":"Ericzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Eleborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wahren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Hedenstierna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840120616-BIB1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1055\/s-2007-1012711","volume":"9","author":"Sherlock","year":"1988","journal-title":"Semin Respir Med"},{"key":"10.1002\/hep.1840120616-BIB2","first-page":"145","volume":"3","author":"Vergnon","year":"1986","journal-title":"Rev Mal Respir"},{"key":"10.1002\/hep.1840120616-BIB3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1056\/NEJM196602102740601","volume":"274","author":"Berth\u00e9lot","year":"1966","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840120616-BIB4","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1164\/ajrccm\/139.3.632","volume":"139","author":"Melot","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"10.1002\/hep.1840120616-BIB5","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/0002-9343(77)90161-9","volume":"63","author":"Wolfe","year":"1977","journal-title":"Am J Med"},{"key":"10.1002\/hep.1840120616-BIB6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0025-6196(12)62438-0","volume":"62","author":"Krowka","year":"1987","journal-title":"Mayo Clin Proc"},{"key":"10.1002\/hep.1840120616-BIB7","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1152\/jappl.1974.36.5.588","volume":"36","author":"Wagner","year":"1974","journal-title":"Theory J Appl Physiol"},{"key":"10.1002\/hep.1840120616-BIB8","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1152\/jappl.1977.42.6.889","volume":"42","author":"Evans","year":"1977","journal-title":"J. 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Bern: Ed Hans Huber, 1971; 177\u2013185."},{"key":"10.1002\/hep.1840120616-BIB26","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1378\/chest.73.4.507","volume":"73","author":"Davis","year":"1978","journal-title":"Chest"},{"key":"10.1002\/hep.1840120616-BIB27","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1172\/JCI100928","volume":"17","author":"Keys","year":"1938","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840120616-BIB28","first-page":"231","volume":"4","author":"Martini","year":"1972","journal-title":"Prog Liver Dis"},{"key":"10.1002\/hep.1840120616-BIB29","first-page":"1085","volume":"135","author":"Rodriguez-Roisin","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.1002\/hep.1840120616-BIB30","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1164\/ajrccm\/140.6.1631","volume":"140","author":"Edell","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"10.1002\/hep.1840120616-BIB31","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1378\/chest.96.5.1064","volume":"96","author":"Castaing","year":"1989","journal-title":"Chest"},{"key":"10.1002\/hep.1840120616-BIB32","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1164\/arrd.1983.127.4.437","volume":"127","author":"McDonnel","year":"1983","journal-title":"Am Rev Respir"},{"key":"10.1002\/hep.1840120616-BIB33","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/0016-5085(85)90503-7","volume":"88","author":"Bruix","year":"1985","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840120616-BIB34","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3109\/00365528009181531","volume":"15","author":"Henriksen","year":"1980","journal-title":"Scand J Gastroenterol"},{"key":"10.1002\/hep.1840120616-BIB35","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S0140-6736(84)92851-4","volume":"1","author":"Hortnagel","year":"1984","journal-title":"Lancet"},{"key":"10.1002\/hep.1840120616-BIB36","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0026-2862(89)90005-8","volume":"38","author":"Nair","year":"1989","journal-title":"Microvasc Res"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840120616","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-199012000-00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:01:39Z","timestamp":1733050899000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-199012000-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,12]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1990]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840120616","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1990,12]]}}}