{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:47:11Z","timestamp":1758707231762,"version":"3.30.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":8644,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Serial sera were collected prospectively during the clinical course of 13 HBsAg carriers with chronic liver disease and analyzed for ALT levels, pre-S<jats:sub>1<\/jats:sub> and pre-S<jats:sub>2<\/jats:sub> antigens and corresponding antibodies and other serological hepatitis B virus markers. In five patients, anti\u2014pre-S<jats:sub>1<\/jats:sub> and anti\u2014pre-S<jats:sub>2<\/jats:sub> antibodies became detectable in multiple serum samples, whereas in eight patients anti\u2014pre-S was never detected or only appeared transiently during the follow-up. The first pattern was associated with normalization of ALT levels and undetectable pre-S antigens and viral DNA by the polymerase chain reaction assay at final follow-up. HBsAg clearance occurred in two of the five patients. The second pattern was one of persistence of HBsAg and pre-S antigens, associated with the presence of serum HBV DNA detectable by spot hybridization or polymerase chain reaction regardless of clinical outcome. These findings demonstrate the occurrence of anti\u2014pre-S antibodies in chronic hepatitis B virus\u2014induced liver disease and associate anti\u2014pre-S appearance with the clearance of hepatitis B virus from serum. (Hepatology 1992;15:26-31).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840150106","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T00:34:12Z","timestamp":1172968452000},"page":"26-31","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["Anti\u2014pre-S responses and viral clearance in chronic hepatitis B virus infection"],"prefix":"10.1097","volume":"15","author":[{"given":"Agata","family":"Budkowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Dubreuil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Poynard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Marcellin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Anne","family":"Loriot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Maillard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Pillot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840150106-BIB1","first-page":"139","volume-title":"Liver cell carcinoma. Dordrecht","author":"Gerlich","year":"1990","unstructured":", , , , , . Structure expression and potential oncogenicity of hepatitis B virus proteins. In: , , eds. Liver cell carcinoma. 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Monoklonale Antik\u00f6rper gegen HBsAg und Aufbau eines Enzymimmunoassays zur Quantifizierung der Subtypen in Monoklonale Antik\u00f6rper Anwendung in der Hedizin. 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