{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T10:49:55Z","timestamp":1792838995656,"version":"4.5.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":8644,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The Long-Evans Cinnamon rat is a mutant strain that contracts hereditary hepatitis and, eventually, spontaneous hepatocellular carcinoma. Because we found a corresponding gross copper accumulation in the liver of the rats, we examined whether the development of hepatitis in our rat system could be prevented by administration of D-penicillamine. D-Penicillamine is a copper-chelating agent and one of the drugs effective for human Wilson\u2019s disease, in which abnormal copper metabolism is also observed. The results show that D-penicillamine treatment inhibited the elevation of serum transaminases, suppressed abnormal histological changes in the liver and completely prevented the onset of hepatitis in the Long-Evans Cinnamon rats. We further found that the copper concentration in the liver and serum copper and ceruloplasmin levels were decreased, whereas the urinary copper level was increased in the D-penicillamine\u2014treated Long-Evans Cinnamon rats. These findings demonstrate that the pathogenesis of hereditary hepatitis in Long-Evans Cinnamon rats is due to abnormal copper accumulation in the liver. (Hepatology 1992;15:82-87).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840150116","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T00:34:12Z","timestamp":1172968452000},"page":"82-87","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":51,"title":["d-penicillamine prevents the development of hepatitis in long-evans cinnamon rats with abnormal copper metabolism"],"prefix":"10.1097","volume":"15","author":[{"given":"Yuji","family":"Togashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Hon","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritoshi","family":"Takeichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Fujioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Nagashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840150116-BIB1","first-page":"4","volume":"14","author":"Sasaki","year":"1985","journal-title":"Rat News Lett"},{"key":"10.1002\/hep.1840150116-BIB2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/oxfordjournals.jhered.a110416","volume":"78","author":"Yoshida","year":"1987","journal-title":"J Hered"},{"key":"10.1002\/hep.1840150116-BIB3","first-page":"1369","volume":"38","author":"Takeichi","year":"1988","journal-title":"Acta Pathol Jpn"},{"key":"10.1002\/hep.1840150116-BIB4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1258\/002367788780864402","volume":"22","author":"Masuda","year":"1988","journal-title":"Lab Animals"},{"key":"10.1002\/hep.1840150116-BIB5","first-page":"705","volume":"90","author":"Namieno","year":"1989","journal-title":"J Jpn Surg Soc (Nippon Geka Gakkai Zasshi)"},{"key":"10.1002\/hep.1840150116-BIB6","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1172\/JCI115208","volume":"87","author":"Li","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840150116-BIB7","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1349-7006.1991.tb01876.x","volume":"82","author":"Li","year":"1991","journal-title":"Jpn J Cancer Res"},{"key":"10.1002\/hep.1840150116-BIB8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/brain\/34.4.295","volume":"34","author":"Wilson","year":"1912","journal-title":"Brain"},{"key":"10.1002\/hep.1840150116-BIB9","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0002-9343(53)90134-X","volume":"15","author":"Bearn","year":"1953","journal-title":"Am J Med"},{"key":"10.1002\/hep.1840150116-BIB10","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/brain\/71.4.410","volume":"71","author":"Cumings","year":"1948","journal-title":"Brain"},{"key":"10.1002\/hep.1840150116-BIB11","doi-asserted-by":"crossref","first-page":"301","DOI":"10.7326\/0003-4819-86-3-301","volume":"86","author":"Roche-Sicot","year":"1977","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840150116-BIB12","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1177\/003693309003500410","volume":"35","author":"O'Donnell","year":"1990","journal-title":"Scott Med J"},{"key":"10.1002\/hep.1840150116-BIB13","first-page":"266","volume":"82","author":"Tores","year":"1990","journal-title":"Bol Asoc Med P R"},{"key":"10.1002\/hep.1840150116-BIB14","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0002-9343(56)90066-3","volume":"21","author":"Walshe","year":"1956","journal-title":"Am J Med"},{"key":"10.1002\/hep.1840150116-BIB15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0065-1281(81)80003-7","volume":"69","author":"Kozma","year":"1981","journal-title":"Acta Histochem"},{"key":"10.1002\/hep.1840150116-BIB16","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1093\/clinchem\/20.12.1556","volume":"20","author":"Schosinsky","year":"1974","journal-title":"Clin Chem"},{"key":"10.1002\/hep.1840150116-BIB17","first-page":"1249","volume-title":"Hepatology","author":"Gollan","year":"1989","unstructured":"Copper metabolism, Wilson's disease, and hepatic copper toxicosis. 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