{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:07:58Z","timestamp":1761764878467,"version":"3.30.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":8584,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>A single injection of D-galactosamine hydrochloride induces acute self-limiting liver disease in rats that morphologically resembles drug-induced hepatitis in human beings. In this immunohistochemical study we examined the localization and expression of the hepatic extracellular matrix components fibronectin, laminin, collagen type I, collagen type III and collagen type IV and of the cell surface receptors (integrins) for fibronectin and laminin. Sections of liver tissue obtained at intervals of 6, 12, 18, 24, 30, 36, 48 and 72 hr and 7 and 21 days after galactosamine administration were immunostained with a panel of polyclonal monospecific antibodies and studied independently by two of us. Fibronectin was the first extracellular matrix component found to be increased, 12 hr after galactosamine injection, followed by collagen type III, and, in a later phase, collagen type IV, type I and laminin. Increased deposition of extracellular matrix was found in areas with liver cell necrosis and along sinusoids. Extracellular matrix immunoreactivity reached a maximum at 36 to 48 hr and decreased thereafter to preinjury levels 3 wk after galactosamine. Immunostaining for the fibronectin and laminin receptors revealed tissue localization identical to that of their ligands. However, the intensity of staining was opposite of that for the extracellular matrix, with a decrease of immunoreactivity after 24 to 48 hr.<\/jats:p>\n            <jats:p>The observed sequence of changes in hepatic extracellular matrix proteins after galactosamine injection resembles the repair reaction in other tissues and may reflect the particular function that each carries out during the process of liver healing after toxic injury. (Hepatology 1992;15:423-431).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840150312","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T00:30:27Z","timestamp":1172968227000},"page":"423-431","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":25,"title":["Immunohistochemical study of extracellular matrix in acute galactosamine hepatitis in rats"],"prefix":"10.1097","volume":"15","author":[{"given":"Mieke A.","family":"Jonker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freke W. J.","family":"Dijkhuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Boes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Machiel J.","family":"Hardonk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joris","family":"Grond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840150312-BIB1|cit1","first-page":"183","volume-title":"Progress of liver diseases","author":"Decker","year":"1972"},{"key":"10.1002\/hep.1840150312-BIB2|cit2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0014-4800(68)90042-7","article-title":"Experimental hepatitis by d-galactosamine","volume":"9","author":"Keppler","year":"1968","journal-title":"Exp Mol Pathol"},{"key":"10.1002\/hep.1840150312-BIB3|cit3","first-page":"189","article-title":"An ultrastructural and histochemical study of the prominent inflammatory response in d(+)-galactosamine hepatotoxicity","volume":"68","author":"MacDonald","year":"1987","journal-title":"Br J Exp Pathol"},{"key":"10.1002\/hep.1840150312-BIB4|cit4","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/hep.1840110415","article-title":"Immunopathology of acute galactosamine hepatitis in rats","volume":"11","author":"Jonker","year":"1990","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840150312-BIB5|cit5","first-page":"140","article-title":"The extracellular matrix in pathology","volume":"111","author":"Bruijn","year":"1988","journal-title":"J Lab Clin Med"},{"key":"10.1002\/hep.1840150312-BIB6|cit6","first-page":"157","article-title":"The extracellular matrix in hepatic regeneration: localization of collagen types I, III, IV, laminin, and fibronectin","volume":"64","author":"Martinez-Hernandez","year":"1991","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840150312-BIB7|cit7","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/hep.1840120312","article-title":"Modulation of extracellular matrix proteins in rat liver during development","volume":"12","author":"Reif","year":"1990","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840150312-BIB8|cit8","first-page":"166","article-title":"The hepatic extracellular matrix. II. Electron immunohistochemical studies in rats with CCl4-induced cirrhosis","volume":"53","author":"Martinez-Hernandez","year":"1985","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840150312-BIB9|cit9","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/ki.1991.63","article-title":"Mechanisms of tubulointerstitial fibrosis","volume":"39","author":"Kuncio","year":"1991","journal-title":"Kidney Int"},{"key":"10.1002\/hep.1840150312-BIB10|cit10","first-page":"65","article-title":"Specific alterations in the distribution of extracellular matrix components within rat myocardium during the development of pressure overload","volume":"64","author":"Contard","year":"1991","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840150312-BIB11|cit11","first-page":"76","article-title":"Localization of type I and III collagen and fibronectin production in injured gastrocnemius muscle","volume":"64","author":"Hurme","year":"1991","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840150312-BIB12|cit12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1055\/s-2008-1040453","article-title":"Effects of extracellular matrix on hepatocyte growth and gene expression: implications for hepatic regeneration and the repair of liver injury","volume":"10","author":"Bucher","year":"1990","journal-title":"Semin Liver Dis"},{"key":"10.1002\/hep.1840150312-BIB13|cit13","first-page":"131","article-title":"From regeneration to scar formation: the collagen way [Editorial]","volume":"64","author":"Rojkind","year":"1991","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840150312-BIB14|cit14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.cb.03.110187.001143","article-title":"Cell surface receptors for extracellular matrix molecules","volume":"3","author":"Buck","year":"1987","journal-title":"Annu Rev Cell Biol"},{"key":"10.1002\/hep.1840150312-BIB15|cit15","first-page":"L331","article-title":"Receptors for extracellular matrix components","volume":"257","author":"McDonald","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1002\/hep.1840150312-BIB16|cit16","first-page":"26","volume-title":"Immunocytochemistry: modern methods and applications","author":"van Noorden","year":"1986"},{"key":"10.1002\/hep.1840150312-BIB17|cit17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/hep.1840070212","article-title":"Characterization of desminpositive rat liver sinusoidal cells","volume":"7","author":"Tsutsumi","year":"1987","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840150312-BIB18|cit18","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF00495000","article-title":"Simultaneous immunohistochemical demonstration of antigen expression and 5-bromodeoxyuridine incorporation in plastic embedded sections","volume":"86","author":"Harms","year":"1987","journal-title":"Histochemistry"},{"key":"10.1002\/hep.1840150312-BIB19|cit19","first-page":"114","article-title":"Methods in laboratory investigation: double immunoenzyme staining method for analysis of tissue and blood lymphocyte subsets with monoclonal antibodies","volume":"56","author":"Chen","year":"1987","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840150312-BIB20|cit20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.RES.47.1.1","article-title":"Some statistical methods useful in circulation research","volume":"47","author":"Wallenstein","year":"1980","journal-title":"Circ Res"},{"key":"10.1002\/hep.1840150312-BIB21|cit21","first-page":"801","article-title":"Immunohistochemical study of fibronectin in experimental myocardial infarction","volume":"137","author":"Casscells","year":"1990","journal-title":"Am J Pathol"},{"key":"10.1002\/hep.1840150312-BIB22|cit22","first-page":"825","article-title":"Fibronectin profiles in normal and chronic wound fluid","volume":"63","author":"Wysocki","year":"1990","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840150312-BIB23|cit23","first-page":"57","article-title":"The hepatic extracellular matrix. I. Electron immunohistochemical studies in normal rat liver","volume":"51","author":"Martinez-Hernandez","year":"1984","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840150312-BIB24|cit24","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/hep.1840100117","article-title":"In situ hybridization for procollagen types I, III and IV mRNA in normal and fibrotic rat liver: evidence for predominant expression in nonparenchymal liver cells","volume":"10","author":"Milani","year":"1989","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840150312-BIB25|cit25","first-page":"611","article-title":"Sequential changes of extracellular matrix and proliferation of ito cells with enhanced expression of desmin and actin in focal hepatic injury","volume":"125","author":"Ogawa","year":"1986","journal-title":"Am J Pathol"},{"key":"10.1002\/hep.1840150312-BIB26|cit26","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/hep.1840110322","article-title":"Connective tissue biology and hepatic fibrosis: report of a conference","volume":"11","author":"Bissell","year":"1990","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840150312-BIB27|cit27","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1055\/s-2008-1040455","article-title":"Cellular sources of noncollagenous matrix proteins: role of fat-storing cells in fibrogenesis","volume":"10","author":"Gressner","year":"1990","journal-title":"Semin Liver Dis"},{"key":"10.1002\/hep.1840150312-BIB28|cit28","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/hep.1840080419","article-title":"Increased production of collagen in vivo by hepatocytes and nonparenchymal cells in rats with carbon tetrachloride-induced hepatic fibrosis","volume":"8","author":"Chojkier","year":"1988","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840150312-BIB29|cit29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0168-8278(89)90076-7","article-title":"In vitro differentiation of fat-storing cells parallels marked increase of collagen synthesis and secretion","volume":"9","author":"Geerts","year":"1989","journal-title":"J Hepatol"},{"key":"10.1002\/hep.1840150312-BIB30|cit30","doi-asserted-by":"crossref","first-page":"10756","DOI":"10.1016\/S0021-9258(18)81686-6","article-title":"Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix","volume":"18","author":"Friedman","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1002\/hep.1840150312-BIB31|cit31","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1055\/s-2008-1040454","article-title":"Cellular sources of collagen and regulation of collagen production in liver","volume":"10","author":"Friedman","year":"1990","journal-title":"Semin Liver Dis"},{"key":"10.1002\/hep.1840150312-BIB32|cit32","first-page":"1193","article-title":"Tissue distribution, quantitation and proliferation kinetics of fat-storing cells in carbon tetrachloride-injured liver","volume":"13","author":"Geerts","year":"1991","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840150312-BIB33|cit33","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/hep.1840120211","article-title":"Immunohistochemistry of the hepatic extracellular matrix in acute viral hepatitis","volume":"12","author":"Inuzuka","year":"1990","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840150312-BIB34|cit34","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/hep.1840130226","article-title":"Effects of cytokines on the liver","volume":"13","author":"Andus","year":"1991","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840150312-BIB35|cit35","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/0014-4827(89)90346-7","article-title":"Rat mesangial cell-matrix interactions in culture","volume":"184","author":"Simonson","year":"1989","journal-title":"Exp Cell Res"},{"key":"10.1002\/hep.1840150312-BIB36|cit36","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0016-5085(91)90478-4","article-title":"Distribution of the VLA family of integrins in normal and pathological human liver tissue","volume":"101","author":"Volpes","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840150312-BIB37|cit37","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1182\/blood.V69.5.1535.1535","article-title":"Platelets express a membrane protein complex immunologically related to the fibroblast fibronectin receptor and distinct from GPIIb\/IIIa","volume":"69","author":"Giancotti","year":"1987","journal-title":"Blood"},{"key":"10.1002\/hep.1840150312-BIB38|cit38","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/336487a0","article-title":"Laminin receptor on platelets is the integrin VLA-6","volume":"336","author":"Sonnenberg","year":"1988","journal-title":"Nature"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840150312","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-199203000-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:04:49Z","timestamp":1733051089000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-199203000-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840150312","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[1992,3]]}}}