{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T02:41:59Z","timestamp":1744166519825,"version":"3.30.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":8584,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The hemodynamic responses to terbutaline - a selective \u03b2<jats:sub>2<\/jats:sub>-adrenoceptor agonist - were studied in conscious normal rats and in conscious rats with secondary biliary cirrhosis. Compared with those of normal rats, dose-response curves in cirrhotic rats indicated significantly decreased reactivity in arterial pressure and heart rate. Half-maximal effective dose was not significantly different between the two groups. Terbutaline induced significant, dose-dependent decreases in portal pressure in both normal rats (9.3%) and cirrhotic rats (13.8%). In normal rats, terbutaline administration (32 \u03bcg \u00b1 min<jats:sup>\u22121<\/jats:sup> \u00b1 kg<jats:sup>\u22121<\/jats:sup> body wt) increased both cardiac output and portal tributary blood flow, thus mimicking hemodynamic changes in cirrhotic rats. In cirrhotic rats, despite a significant increase in portal tributary blood flow (from 19.9 \u00b1 1.7 ml\/min to 22.7 \u00b1 1.5 ml\/min), terbutaline decreased portal pressure from 17.4 \u00b1 1.0 mm Hg to 15.0 \u00b1 0.8 mm Hg. This study indicates that increased \u03b2<jats:sub>2<\/jats:sub>-adrenoceptor stimulation in cirrhotic rats may be involved in hyperdynamic circulation. The association of a decreased portal pressure and increased splanchnic blood flow suggests that \u03b2<jats:sub>2<\/jats:sub>-adrenoceptor stimulation may modulate hepatic and portal collateral vascular resistance. (Hepatology 1992;15:459-463).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840150318","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T00:30:27Z","timestamp":1172968227000},"page":"459-463","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Hemodynamic effects of terbutaline, a \u03b22-adrenoceptor agonist, in conscious rats with secondary biliary cirrhosis"],"prefix":"10.1097","volume":"15","author":[{"given":"Jorge 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