{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:29:01Z","timestamp":1791044941566,"version":"4.1.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":8553,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Liver samples from patients with three different types of liver diseases, alveolar echinococcosis (a dense and irreversible fibrosis), hepatocellular carcinoma and alcoholic cirrhosis, were analyzed for their content in hydroxypyridinium cross\u2013links found in mature collagen. We demonstrated the presence of small amounts of pyridinoline in control livers (0.27 \u00b1 0.06 pmol\/pmol of collagen). Pyridinoline content was increased in fibrotic livers, with the highest values found in patients with alveolar echinococcosis (up to 1.33 pmol\/pmol of collagen). The deoxy analogue of pyridinoline was not detected in either normal or fibrotic livers. Pyridinoline levels, expressed as picomoles per picomole of collagen, were similar in all patients with carcinoma (0.7 \u00b1 0.05 pmol\/pmol of collagen). They were heterogeneous in patients with alveolar echinococcosis and were particularly high in patients with alcoholic cirrhosis (1.04 \u00b1 0.11 pmol\/pmol of collagen). These results demonstrate for the first time the presence of an hydroxypyridinium cross\u2013link in liver fibrosis and suggest that pyridinoline measurement might be an important criterion in assessing the irreversibility of human liver fibrosis. (Hepatology 1992;15:599-602).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840150408","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T00:41:46Z","timestamp":1172968906000},"page":"599-602","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":69,"title":["Hydroxypyridinium Collagen Cross\u2013Links in Human Liver Fibrosis: Study of Alveolar Echinococcosis"],"prefix":"10.1097","volume":"15","author":[{"given":"Sylvie","family":"Ricard-Blum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange","family":"Bresson-Hadni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique-Ang\u00e8le","family":"Vuitton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Ville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Alexis","family":"Grimaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840150408-BIB1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1042\/bj1810639","volume":"181","author":"Vater","year":"1979","journal-title":"Biochem J"},{"key":"10.1002\/hep.1840150408-BIB2","first-page":"237","volume":"7","author":"Herbage","year":"1983","journal-title":"Contr Microbiol Immunol"},{"key":"10.1002\/hep.1840150408-BIB3","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/0003-2697(84)90101-5","volume":"137","author":"Eyre","year":"1984","journal-title":"Anal Biochem"},{"key":"10.1002\/hep.1840150408-BIB4","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/hep.1840120329","volume":"12","author":"Vuitton","year":"1990","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840150408-BIB5","first-page":"67","volume":"78","author":"Vuitton","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840150408-BIB6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF00927740","volume":"72","author":"Vuitton","year":"1986","journal-title":"Z Parasitenkd"},{"key":"10.1002\/hep.1840150408-BIB7","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/0003-9861(61)90291-0","volume":"93","author":"Woessner","year":"1961","journal-title":"Arch Biophys Biochem"},{"key":"10.1002\/hep.1840150408-BIB8","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0021-9258(18)56248-7","volume":"184","author":"Neuman","year":"1950","journal-title":"J Biol Chem"},{"key":"10.1002\/hep.1840150408-BIB9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0003-2697(88)90274-6","volume":"169","author":"Black","year":"1988","journal-title":"Anal Biochem"},{"key":"10.1002\/hep.1840150408-BIB10","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1146\/annurev.bi.53.070184.003441","volume":"53","author":"Eyre","year":"1984","journal-title":"Annu Rev Biochem"},{"key":"10.1002\/hep.1840150408-BIB11","first-page":"137","volume-title":"Collagen","author":"Rojkind","year":"1988","unstructured":". The liver as a bioecological system: modifications during regeneration and repair. In: ed. Collagen. Vol II. Boca Raton, FL: CRC Press, 1988: 137\u2013159."},{"key":"10.1002\/hep.1840150408-BIB12","first-page":"307","volume":"141","author":"Last","year":"1990","journal-title":"Am J Pathol"},{"key":"10.1002\/hep.1840150408-BIB13","first-page":"491","volume-title":"Marker protein in inflammation","volume":"3","author":"Vuitton","year":"1986","unstructured":", , , , . Development of fibrosis in hepatic alveolar echinococcosis: a sequential study in mice infected with Echinococcus multilocularis. In: , , eds. Marker protein in inflammation. Vol 3. 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