{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:44:16Z","timestamp":1758278656242,"version":"3.30.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":8553,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The Dubin\u2013Johnson syndrome is manifested by conjugated hyperbilirubinemia and pigment accumulation in hepatocellular lysosomes. The TR\u2013 rat model is a phenotypic model of the Dubin\u2013Johnson syndrome and is characterized by defective ATP\u2013dependent transport of a group of nonbile acid organic anions, including glutathione\u2013S\u2013conjugates and oxidized glutathione, across the bile canaliculus. Similar ATP\u2013dependent transport mechanisms have been described in erythrocytes. Intact erythrocytes and inverted erythrocyte membrane vesicles from Dubin\u2013Johnson patients, TR\u2013rats and appropriate controls were studied with regard to ATP\u2013dependent transport of dinitrophenyl glutathione and oxidized glutathione. No significant differences were observed, indicating that the erythrocyte and canalicular ATP\u2013dependent transporters for these substrates are functionally and potentially genetically distinct. (Hepatology 1992;15:722-725).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840150428","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T00:41:46Z","timestamp":1172968906000},"page":"722-725","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":26,"title":["Erythrocyte Membrane Transport of Glutathione Conjugates and Oxidized Glutathione in the Dubin\u2013Johnson Syndrome and in Rats With Hereditary Hyperbilirubinemia"],"prefix":"10.1097","volume":"15","author":[{"given":"Philip","family":"Board","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshirou","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zenaida","family":"Gatmaitan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxin","family":"Che","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irwin M.","family":"Arias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840150428-BIB1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00005792-195409000-00001","volume":"33","author":"Dubin","year":"1954","journal-title":"Medicine"},{"key":"10.1002\/hep.1840150428-BIB2","doi-asserted-by":"crossref","first-page":"952","DOI":"10.7326\/0003-4819-41-5-952","volume":"41","author":"Sprinz","year":"1954","journal-title":"Ann Int Med"},{"key":"10.1002\/hep.1840150428-BIB3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1056\/NEJM197301182880301","volume":"288","author":"Wolkoff","year":"1973","journal-title":"New Engl J Med"},{"key":"10.1002\/hep.1840150428-BIB4","first-page":"549","volume":"39","author":"Shani","year":"1970","journal-title":"Q J Med"},{"key":"10.1002\/hep.1840150428-BIB5","first-page":"1367","volume-title":"The metabolic basis of inherited disease","author":"Roy Chowdhury","year":"1989","unstructured":", . 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