{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:27:49Z","timestamp":1790263669929,"version":"4.1.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":8523,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,5]]},"abstract":"<jats:title>\n                           <jats:bold>ABSTRPlCT<\/jats:bold>\n                        <\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>Hypercholesterolemia is commonly associated with primary biliary cirrhosis. In the general population, elevated serum cholesterol is associated with an increased risk of atherosclerosis. The relative risk has been poorly defined in primary biliary cirrhosis patients with hyperlipidemia. In addition, the hyperlipidemic state seen with primary biliary cirrhosis has not been well studied. We prospectively observed 312 patients with primary biliary cirrhosis for a median of 7.4 yr. During this period, 128 patients died. The incidence of atherosclerotic death in patients with primary biliary cirrhosis was not statistically different when compared with an age\u2013matched and sex\u2013matched U.S. control population. A similar group of 50 consecutive PBC patients had detailed serum lipid profiles. Findings included progressive increases in total cholesterol and low\u2013density lipoprotein cholesterol with an increasing histological stage or severity of disease. High\u2013density lipoprotein cholesterol was elevated in all stages, with the highest levels in histological stage 2 and 3 disease. Triglycerides were normal or slightly elevated in all stages. Apoprotein A\u2013I was elevated in all but histological stage 4 disease. Our study suggests the hyperlipidemia associated with primary biliary cirrhosis does not place these patients at risk for atherosclerotic death. In light of the limitations imposed by our relatively small sample size, however, additional patients should be studied. Furthermore, an examination of the pathophysiological mechanisms leading to hypercholesterolemia should be the topic of further study. (Hepatology 1992;15:858-862).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840150518","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T00:43:08Z","timestamp":1172968988000},"page":"858-862","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":132,"title":["Hypercholesterolemia and Atherosclerosis in Primary Biliary Cirrhosis: What Is the Risk?"],"prefix":"10.1097","volume":"15","author":[{"given":"Jeffrey S.","family":"Crippin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kieth D.","family":"Lindor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Jorgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Kottke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay M.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Murtaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolland E.","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840150518-BIB1","first-page":"487","volume-title":"Progress in liver diseases","volume":"6","author":"Dickson","year":"1979","unstructured":", . Primary biliary cirrhosis. In: , eds. Progress in liver diseases. Vol. 6. New York: Grune & Stratton, 1979: 487\u2013502."},{"key":"10.1002\/hep.1840150518-BIB2","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/0016-5085(90)91091-J","volume":"98","author":"Balasubramaniam","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840150518-BIB3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/gut.16.5.379","volume":"16","author":"McIntyre","year":"1975","journal-title":"Gut"},{"key":"10.1002\/hep.1840150518-BIB4","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0016-5085(82)80212-6","volume":"83","author":"Sabesin","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840150518-BIB5","first-page":"65","volume-title":"Liver and biliary disease: pathophysiology, diagnosis, management","author":"Harry","year":"1985","unstructured":", . The effect of liver disease on plasma lipids and lipoproteins. In: , , , eds. Liver and biliary disease: pathophysiology, diagnosis, management. 2nd ed. Philadelphia: W.B. Saunders Co., 1985: 65\u201385."},{"key":"10.1002\/hep.1840150518-BIB6","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/0016-5085(85)90642-0","volume":"89","author":"Jahn","year":"1985","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840150518-BIB7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00005792-195012000-00002","volume":"29","author":"Ahrens","year":"1950","journal-title":"Medicine (Baltimore)"},{"key":"10.1002\/hep.1840150518-BIB8","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S0016-5085(19)34715-8","volume":"47","author":"Foulk","year":"1964","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840150518-BIB9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0002-9343(50)90015-5","volume":"9","author":"Bevans","year":"1950","journal-title":"Am J Med"},{"key":"10.1002\/hep.1840150518-BIB10","doi-asserted-by":"crossref","first-page":"845","DOI":"10.7326\/0003-4819-38-4-845","volume":"38","author":"Miller","year":"1953","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840150518-BIB11","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/BF02232356","volume":"5","author":"Hoffbauer","year":"1960","journal-title":"Am J Dig Dis [New Series]"},{"key":"10.1002\/hep.1840150518-BIB12","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0016-5085(69)80012-0","volume":"56","author":"Schaffner","year":"1969","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840150518-BIB13","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJM198504183121602","volume":"312","author":"Dickson","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840150518-BIB14","year":"1978","unstructured":"International Classifications of Diseases, Ninth Revision. Clinical Modification, Vol. 1, Diseases: tabular lists. Commission on Professional and Hospital Activities, 1978: 388\u2013389."},{"key":"10.1002\/hep.1840150518-BIB15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0010-4809(74)90010-X","volume":"7","author":"Monson","year":"1974","journal-title":"Comput Biomed Res"},{"key":"10.1002\/hep.1840150518-BIB16","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/BF02531988","volume":"8","author":"Quarfordt","year":"1973","journal-title":"Lipids"},{"key":"10.1002\/hep.1840150518-BIB17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1084\/jem.95.1.19","volume":"95","author":"Byers","year":"1952","journal-title":"J Exp Med"},{"key":"10.1002\/hep.1840150518-BIB18","first-page":"121","volume-title":"Bile acids in human diseases","author":"Weis","year":"1972","unstructured":". Causes of hypercholesterolemia after biliary ligation in the rat. In: , eds. Bile acids in human diseases. Stuttgart: Schattauer, 1972: 121\u2013123."},{"key":"10.1002\/hep.1840150518-BIB19","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1084\/jem.99.1.43","volume":"99","author":"Frederickson","year":"1954","journal-title":"J Exp Med"},{"key":"10.1002\/hep.1840150518-BIB20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0005-2760(73)90061-1","volume":"296","author":"Harry","year":"1973","journal-title":"Biochim Biophys Acta"},{"key":"10.1002\/hep.1840150518-BIB21","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1016\/S0021-9258(19)70824-2","volume":"237","author":"Byers","year":"1962","journal-title":"J Biol Chem"},{"key":"10.1002\/hep.1840150518-BIB22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF02531930","volume":"4","author":"Byers","year":"1969","journal-title":"Lipids"},{"key":"10.1002\/hep.1840150518-BIB23","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1172\/JCI106085","volume":"48","author":"Seidel","year":"1969","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840150518-BIB24","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1172\/JCI106459","volume":"49","author":"Seidel","year":"1971","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840150518-BIB25","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1042\/cs0540369","volume":"54","author":"Agorastos","year":"1978","journal-title":"Clin Sci"},{"key":"10.1002\/hep.1840150518-BIB26","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1172\/JCI106585","volume":"50","author":"Norum","year":"1971","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840150518-BIB27","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0009-8981(81)90245-X","volume":"115","author":"Fujii","year":"1981","journal-title":"Clin Chim Acta"},{"key":"10.1002\/hep.1840150518-BIB28","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0022-2275(20)38312-7","volume":"30","author":"Desai","year":"1989","journal-title":"J Lipid Res"},{"key":"10.1002\/hep.1840150518-BIB29","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1056\/NEJM196109072651004","volume":"265","author":"VanItallie","year":"1961","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840150518-BIB30","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0016-5085(65)80106-8","volume":"48","author":"Schaffner","year":"1965","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840150518-BIB31","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0016-5085(19)33896-X","volume":"57","author":"Schaffner","year":"1969","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840150518-BIB32","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0002-8703(86)90155-9","volume":"111","author":"Lerner","year":"1986","journal-title":"Am Heart J"},{"key":"10.1002\/hep.1840150518-BIB33","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0140-6736(86)90597-0","volume":"2","author":"Martin","year":"1986","journal-title":"Lancet"},{"key":"10.1002\/hep.1840150518-BIB34","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1001\/jama.1986.03380200061022","volume":"256","author":"Stamler","year":"1986","journal-title":"JAMA"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840150518","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-199205000-00017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T17:24:04Z","timestamp":1729272244000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-199205000-00017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840150518","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1992,5]]}}}