{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:17:11Z","timestamp":1789942631128,"version":"4.0.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":8492,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,6]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>To explore a possible role for adenosine in the pathogenesis of the splanchnic hyperemia of cirrhosis, we administered 8\u2013phenyltheophylline, a specific adenosine receptor antagonist, to rats with biliary cirrhosis caused by bile duct ligation and to control shamoperated rats. Micro\u2013Doppler flow studies showed that a 10\u2013\u03bcmol\/kg dose of 8\u2013phenyltheophylline completely abolished the superior mesenteric hyperemic response to infusions of exogenous adenosine in both cirrhotic and control rats. Analysis of regional blood flows by radioactive microspheres demonstrated that this dose of 8\u2013phenyltheophylline in cirrhotic rats significantly increased portal tributary vascular resistance by 60% and decreased portal tributary blood flow by 26%. This decrease was entirely the result of a 42% reduction in the intestinal blood flow. 8\u2013phenyltheophylline did not affect cardiac output, arterial pressure or any other extrasplanchnic hemodynamic variables in cirrhotic rats. No detectable effect of 8\u2013phenyltheophylline was seen in sham\u2013operated rats. These results suggest that adenosine may be involved in the genesis of splanchnic hyperemia in cirrhotic rats. (Hepatology 1992;15:1107-1111).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840150622","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T00:42:06Z","timestamp":1172968926000},"page":"1107-1111","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["Adenosine Receptor Blockade Reduces Splanchnic Hyperemia in Cirrhotic Rats"],"prefix":"10.1097","volume":"15","author":[{"given":"Samuel S.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa E.","family":"Chilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Min","family":"Pak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840150622-BIB1","first-page":"231","volume-title":"Progress in liver diseases","volume":"4","author":"Martini","year":"1972","unstructured":", . 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