{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T16:41:01Z","timestamp":1777135261060,"version":"3.51.4"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":8462,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The hepatocytic entry of acetaminophen sulfate conjugate was examined in the rat liver, perfused with red cells with and without albumin, by use of the multiple\u2013indicator dilution technique. [<jats:sup>3<\/jats:sup>H]acetaminophen sulfate was injected into the portal vein in a bolus of blood containing<jats:sup>51<\/jats:sup>Cr\u2013labeled red blood cells (a vascular reference), sucrose (a low\u2013molecular\u2013weight interstitial reference) or<jats:sup>125<\/jats:sup>I\u2013labeled albumin (a high\u2013molecular\u2013weight interstitial reference, included when albumin was present), and the time courses of their outflow into the hepatic venous blood were observed. The [<jats:sup>3<\/jats:sup>H]acetaminophen sulfate, which binds partially to albumin, emerged between albumin and sucrose in the presence of albumin, precessed the upslope of the sucrose curve and showed a late low\u2013in\u2013magnitude tailing; the precession disappeared in the absence of albumin. Biliary excretion of [<jats:sup>3<\/jats:sup>H]acetaminophen sulfate was less than 1% of the dose. Quantitative evaluation with a barrier\u2013limited, spacedistributed variable transit time model (including rapidly equilibrating albumin binding) accounted for the albumin effect on [<jats:sup>3<\/jats:sup>H]acetaminophen sulfate behavior and demonstrated a low liver cell permeability for the acetaminophen sulfate and a small interstitial binding space for its nonalbumin\u2013bound fraction in excess of that for sucrose, which in the absence of albumin was of similar dimensions. (Hepatology 1992;16:173-190.)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840160129","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T01:22:54Z","timestamp":1172971374000},"page":"173-190","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":46,"title":["Uptake of A Protein\u2013Bound Polar Compound, Acetaminophen Sulfate, by Perfused Rat Liver"],"prefix":"10.1097","volume":"16","author":[{"given":"Carl A.","family":"Goresky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandy K.","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas J.","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ford Barker","family":"Iii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy F.","family":"Cherry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen G.","family":"Bach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840160129-BIB1","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1126\/science.6258226","volume":"211","author":"Weisiger","year":"1981","journal-title":"Science"},{"key":"10.1002\/hep.1840160129-BIB2","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1073\/pnas.82.5.1563","volume":"42","author":"Weisiger","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hep.1840160129-BIB3","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1172\/JCI112920","volume":"79","author":"Weisiger","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.1840160129-BIB4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/978-1-4684-5463-5_12","volume-title":"Pharmacokinetics: mathematical and statistical approaches to metabolism and distribution of chemicals and drugs","author":"Bass","year":"1988","unstructured":". 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