{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:55:55Z","timestamp":1791323755461,"version":"4.3.1"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":8431,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,8]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Ursodeoxycholic acid was recently recognized as an effective agent in the treatment of primary biliary cirrhosis. Experimental evidence supporting the usefulness of ursodeoxycholic acid as a potentially beneficial therapeutic agent for primary biliary cirrhosis has been reported from the biochemical and physiological aspects.<\/jats:p>\n            <jats:p>In this study, we investigated the direct effects of ursodeoxycholic acid on immunoglobulin and cytokine production <jats:italic toggle=\"yes\">in vitro<\/jats:italic> using plaque\u2013forming cell assay and enzyme\u2013linked immunosorbent assay. It was demonstrated that ursodeoxycholic acid suppressed the production of IgM, IgG and IgA induced by <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic> Cowan I in peripheral blood mononuclear cells derived from healthy subjects and patients with primary biliary cirrhosis and also in human B lymphoma cell lines. Furthermore, ursodeoxycholic acid suppressed interleukin\u20132 and interleukin\u20134 production induced by concanavalin A and interferon\u2013\u03b3 production induced by polyinosinic\u2013polycytidylic acid, but it did not affect interleukin\u20131 and interleukin\u20136 production induced by lipopolysaccharide in peripheral blood mononuclear cells. In addition, ursodeoxycholic acid suppressed the concanavalin A\u2013induced thymocyte proliferation mediated by interleukin\u20131. Cytotoxicity against lymphocytes was not observed at the concentrations of ursodeoxycholic acid used. These results suggest that the beneficial effect of ursodeoxycholic acid in primary biliary cirrhosis is mediated in part by immunosuppression. (Hepatology 1992;16:358-364.)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840160213","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T01:12:14Z","timestamp":1172970734000},"page":"358-364","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":194,"title":["Immunomodulatory Effects of Ursodeoxycholic Acid on Immune Responses"],"prefix":"10.1097","volume":"16","author":[{"given":"Masahide","family":"Yoshikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadasu","family":"Tsujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Matsumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junnichi","family":"Yamao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Matsumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryouichi","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeaki","family":"Ishizaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840160213-BIB1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1056\/NEJM198702263160907","volume":"316","author":"Kaplan","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840160213-BIB2","first-page":"1158","volume-title":"Hepatology: a textbook of liver disease","author":"Vierling","year":"1990","unstructured":"Primary biliary cirrhosis. In: , eds. Hepatology: a textbook of liver disease. 2nd ed. Philadelphia: W.B. Saunders, 1990: 1158\u20131205."},{"key":"10.1002\/hep.1840160213-BIB3","first-page":"861","volume-title":"Liver and biliary disease","author":"Sherlock","year":"1985","unstructured":"Primary biliary cirrhosis. In: , , , eds. Liver and biliary disease. 2nd ed. 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