{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:13:26Z","timestamp":1759742006736,"version":"3.30.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":8370,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,10]]},"abstract":"<jats:title>\n                           <jats:bold>ABSTRACT<\/jats:bold>\n                        <\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>There is increasing evidence that primary biliary cirrhosis is associated with an alteration of the immune system. Although the cause remains unknown, it has been suggested that the immune system of patients with primary biliary cirrhosis is involved in the pathogenesis of their disease. We have investigated the T\u2013cell function in patients with primary biliary cirrhosis and have found defective phytohemagglutinin\u2013induced T\u2013cell mitogenesis. Likewise, their blastogenic response to CD3 monoclonal antibody was also depressed, although the DNA synthesis induced by stimulation with phorbol esters (12\u2013O\u2013tetradecanoilphorbol\u201313\u2013acetate) plus ionophore (ionomycin) was normal. These alterations could not be ascribed either to a decreased synthesis of interleukin\u20132 or to a defective expression of interleukin\u20132 receptor after cellular activation. Moreover, this defective proliferative response of T lymphocytes was observed even in the presence of saturating concentrations of exogenous interleukin\u20132. These results represent evidence of the deficiency in the interleukin\u20132\u2014dependent pathway found in T lymphocytes from patients with primary biliary cirrhosis. (HEPATOLOGY 1992;16:931-936.)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840160413","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T01:22:37Z","timestamp":1172971357000},"page":"931-936","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Deficient Interleukin\u20132 Responsiveness of T Lymphocytes From Patients With Primary Biliary Cirrhosis"],"prefix":"10.1097","volume":"16","author":[{"given":"Jos\u00e9 Luis","family":"Men\u00e9ndez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Antonio","family":"Gir\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Manzano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelio","family":"Garrido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Abreu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agustin","family":"Albillos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Dur\u00e1ntez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melchor","family":"Alvarez-Mon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840160413-BIB1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1056\/NEJM198702263160907","volume":"316","author":"Kaplan","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840160413-BIB2","doi-asserted-by":"crossref","first-page":"500","DOI":"10.7326\/0003-4819-99-4-500","volume":"99","author":"James","year":"1983","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840160413-BIB3","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0167-5699(88)91214-5","volume":"9","author":"Marcos","year":"1988","journal-title":"Immunol Today"},{"key":"10.1002\/hep.1840160413-BIB4","first-page":"35","volume":"15","author":"MacSween","year":"1973","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/hep.1840160413-BIB5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1136\/gut.14.2.89","volume":"14","author":"Fox","year":"1973","journal-title":"Gut"},{"key":"10.1002\/hep.1840160413-BIB6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0008-8749(73)90009-9","volume":"6","author":"Newberry","year":"1973","journal-title":"Cell Immunol"},{"key":"10.1002\/hep.1840160413-BIB7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0016-5085(80)90570-3","volume":"78","author":"Gianni","year":"1980","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840160413-BIB8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4049\/jimmunol.129.1.81","volume":"129","author":"Logie","year":"1982","journal-title":"J Immunol"},{"key":"10.1002\/hep.1840160413-BIB9","first-page":"143","volume":"8","author":"Behrens","year":"1982","journal-title":"J Clin Lab Immunol"},{"key":"10.1002\/hep.1840160413-BIB10","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0140-6736(80)92481-2","volume":"2","author":"Routhier","year":"1980","journal-title":"Lancet"},{"key":"10.1002\/hep.1840160413-BIB11","doi-asserted-by":"crossref","first-page":"385","DOI":"10.7326\/0003-4819-100-3-385","volume":"100","author":"Miller","year":"1984","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840160413-BIB12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0090-1229(81)90184-7","volume":"20","author":"Cancellerini","year":"1981","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1002\/hep.1840160413-BIB13","first-page":"490a","volume":"32","author":"Kershenobich","year":"1984","journal-title":"Clin Res"},{"key":"10.1002\/hep.1840160413-BIB14","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev.iy.05.040187.002443","volume":"5","author":"Allison","year":"1987","journal-title":"Annu Rev Immunol"},{"key":"10.1002\/hep.1840160413-BIB15","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0092-8674(86)90279-5","volume":"45","author":"Goverman","year":"1986","journal-title":"Cell"},{"key":"10.1002\/hep.1840160413-BIB16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0167-5699(86)90009-5","volume":"7","author":"Isakov","year":"1986","journal-title":"Immunol Today"},{"key":"10.1002\/hep.1840160413-BIB17","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1126\/science.3008337","volume":"232","author":"Waldmann","year":"1986","journal-title":"Science"},{"key":"10.1002\/hep.1840160413-BIB18","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.4049\/jimmunol.135.5.3087","volume":"135","author":"Mills","year":"1985","journal-title":"J Immunol"},{"key":"10.1002\/hep.1840160413-BIB19","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.4049\/jimmunol.137.12.3758","volume":"137","author":"Davis","year":"1986","journal-title":"J Immunol"},{"key":"10.1002\/hep.1840160413-BIB20","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/0167-5699(87)90238-6","volume":"8","author":"Dr\u00f6ge","year":"1987","journal-title":"Immunol Today"},{"key":"10.1002\/hep.1840160413-BIB21","first-page":"265","volume":"87","author":"Moreno","year":"1986","journal-title":"Med Clin (Barc)"},{"key":"10.1002\/hep.1840160413-BIB22","doi-asserted-by":"crossref","first-page":"533","DOI":"10.7326\/0003-4819-77-4-533","volume":"77","author":"Klatskin","year":"1972","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840160413-BIB23","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1182\/blood.V67.1.228.228","volume":"67","author":"Alvarez-Mon","year":"1986","journal-title":"Blood"},{"key":"10.1002\/hep.1840160413-BIB24","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.4049\/jimmunol.120.6.2027","volume":"120","author":"Gillis","year":"1978","journal-title":"J Immunol"},{"key":"10.1002\/hep.1840160413-BIB25","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1002\/eji.1830181126","volume":"18","author":"Al\u00e9s-Mart\u00ednez","year":"1988","journal-title":"Eur J Immunol"},{"key":"10.1002\/hep.1840160413-BIB26","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/art.1780250209","volume":"25","author":"Cohen","year":"1982","journal-title":"Arthritis Rheum"},{"key":"10.1002\/hep.1840160413-BIB27","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/BF00916555","volume":"8","author":"Gaspar","year":"1988","journal-title":"J Clin Immunol"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840160413","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-199210000-00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:06:40Z","timestamp":1733051200000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-199210000-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,10]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840160413","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[1992,10]]}}}