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Sequences that flanked the transgenic integration site were cloned and mapped to mouse chromosome 4, between the <jats:italic toggle=\"yes\">Tsha<\/jats:italic> and <jats:italic toggle=\"yes\">Hxb<\/jats:italic> loci. During early embryonic development, the direction of postimplantation turning, one of the earliest manifestations of left-right asymmetry, was reversed in homozygous transgenic embryos. This insertional mutation identifies a gene that controls embryonic turning and visceral left-right polarity.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840190138","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T02:27:49Z","timestamp":1172975269000},"page":"257-258","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["What\u2019s wrong when it isn\u2019t right: Situs inversus and genetic control of organ position"],"prefix":"10.1097","volume":"19","author":[{"given":"Laurie N.","family":"Fishman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel E.","family":"Lavine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840190138-BIB1","first-page":"202","volume-title":"Biological Asymmetry and Handedness","author":"Breuckner","year":"1991","unstructured":", . 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