{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:45:58Z","timestamp":1790232358194,"version":"4.1.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":7823,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Nonarterialized orthotopic liver transplantation with no immunosuppression was performed in 13 mouse-strain combinations. Two strain combinations with major histocompatibility complex class I and class II and minor histocompatibility complex disparity had 20% and 33% survival of more than 100 days, but the other 11 combinations, including four that were fully allogeneic and all with only class I, class II or minor disparities, yielded 45% to 100% survival of more than 100 days. Long-living recipients permanently accepted donor-strain heterotopic hearts transplanted on the same day or donor-strain skin 3 mo after liver transplantation, in spite of detectable antidonor <jats:italic toggle=\"yes\">in vitro<\/jats:italic> activity with mixed lymphocyte reaction and cellmediated lymphocytotoxicity testing (split tolerance). In further donor-specific experiments, liver grafts were not rejected by presensitized major histocompatibility complex class I-disparate recipients and they protected donor-strain skin grafts from second set (or any) rejection. Less frequently, liver transplantation rescued rejecting skin grafts placed 1 wk earlier in major histocompatibility complex class I, class II and minor histocompatibility complex, class II or minor histocompatibility complex-disparate strain combinations. Donor-derived leukocyte migration to the central lymphoid organs occurred within 1 to 2 hr after liver transplantation in all animals examined, persisted in the surviving animals until they were killed (&gt;375 days), and was demonstrated with double-immunolabeling to be multilineage. The relation of these findings to so-called hepatic tolerogenicity and to tolerance in general is discussed. (Hepatology 1994;19:916-924.)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840190418","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T02:46:54Z","timestamp":1172976414000},"page":"916-924","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":339,"title":["Murine liver allograft transplantation: Tolerance and donor cell chimerism"],"prefix":"10.1097","volume":"19","author":[{"given":"Shigwang","family":"Qian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Demetris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Murase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul S.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Fung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Starzl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840190418-BIB1","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/0140-6736(92)91840-5","volume":"339","author":"Starzl","year":"1992","journal-title":"Lancet"},{"key":"10.1002\/hep.1840190418-BIB2","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/0140-6736(92)93286-V","volume":"340","author":"Starzl","year":"1992","journal-title":"Lancet"},{"key":"10.1002\/hep.1840190418-BIB3","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1056\/NEJM199303183281101","volume":"328","author":"Starzl","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840190418-BIB4","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1097\/00007890-199306000-00012","volume":"55","author":"Starzl","year":"1993","journal-title":"Transplantation"},{"key":"10.1002\/hep.1840190418-BIB5","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/0167-5699(93)90054-O","volume":"14","author":"Starzl","year":"1993","journal-title":"Immunol Today"},{"key":"10.1002\/hep.1840190418-BIB6","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1002\/hep.1840170629","volume":"17","author":"Starzl","year":"1993","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840190418-BIB7","first-page":"3341","volume":"25","author":"Demetris","year":"1993","journal-title":"Transplant Proc"},{"key":"10.1002\/hep.1840190418-BIB8","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1084\/jem.137.5.1142","volume":"137","author":"Steinman","year":"1973","journal-title":"J Exp Med"},{"key":"10.1002\/hep.1840190418-BIB9","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1084\/jem.139.2.380","volume":"139","author":"Steinman","year":"1974","journal-title":"J Exp Med"},{"key":"10.1002\/hep.1840190418-BIB10","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/00007890-199109000-00039","volume":"52","author":"Qian","year":"1991","journal-title":"Transplantation"},{"key":"10.1002\/hep.1840190418-BIB11","first-page":"733","volume":"111","author":"Starzl","year":"1960","journal-title":"Surg Gynecol Obstet"},{"key":"10.1002\/hep.1840190418-BIB12","first-page":"659","volume":"117","author":"Starzl","year":"1963","journal-title":"Surg Gynecol Obstet"},{"key":"10.1002\/hep.1840190418-BIB13","first-page":"5621","volume":"260","author":"Garnier","year":"1965","journal-title":"C R Acad Sci (Paris)"},{"key":"10.1002\/hep.1840190418-BIB14","first-page":"571","volume":"11","author":"Zimmerman","year":"1979","journal-title":"Transplant Proc"},{"key":"10.1002\/hep.1840190418-BIB15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0022-5223(19)42744-X","volume":"7","author":"Ono","year":"1969","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1002\/hep.1840190418-BIB16","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/172603a0","volume":"172","author":"Billingham","year":"1953","journal-title":"Nature"},{"key":"10.1002\/hep.1840190418-BIB17","author":"Rao","unstructured":", , , , , . 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The role of passenger leukocytes in rejection and \u201ctolerance\u201d after solid organ transplantation: a potential explanation of a paradox. Proceedings of Twenty-Fifth International Conference on Transplantation and Clinical Immunology, Lyon, France. 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