{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T05:03:05Z","timestamp":1733115785304,"version":"3.30.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":7823,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>To compare octreotide with injection sclerotherapy in the treatment of acute variceal hemorrhage, patients admitted with gastrointestinal bleeding and oesophageal varices confirmed by endoscopy were randomised to receive either emergency sclerotherapy with 3% sodium tetradecyl sulphate or octreotide (50 \u03bcg intravenous bolus plus 50 \u03bcg per hr intravenous infusion for 48 hr). At the end of the study period (48 hr), the octreotide group also had sclerotherapy to obliterate the varices.<\/jats:p>\n            <jats:p>One hundred patients were recruited. Demographic features including the aetiology of portal hypertension and the Child-Pugh\u2019s grading of the two groups were similar. Bleeding was initially controlled in 90% of patients by emergency sclerotherapy and in 84% by octreotide infusion (95% confidence interval 0-19.5, p = 0.55). There were no significant differences between the two groups in early (within 48 hr of randomisation) rebleeding (16% vs 14%), blood transfusion (3 units vs 3.51, hospital stay (5 days vs 6 days), or hospital mortality (27% vs 20%). No notable side-effects were associated with octreotide.<\/jats:p>\n            <jats:p>We conclude that octreotide infusion and emergency sclerotherapy are equally effective in controlling variceal haemorrhage.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840190435","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T02:46:54Z","timestamp":1172976414000},"page":"1051-1054","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Hold that needle: Octreotide for acute variceal hemorrhage"],"prefix":"10.1097","volume":"19","author":[{"given":"William 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